发明申请
US20060106207A1 Nucleotide sequences that encode deregulated phosphoglycerate dehydrogenases of coryneform bacteria and method for producing l-serine
失效
编码棒状杆菌细菌脱磷酸甘油酸脱氢酶的核苷酸序列和产生l-丝氨酸的方法
- 专利标题： Nucleotide sequences that encode deregulated phosphoglycerate dehydrogenases of coryneform bacteria and method for producing l-serine
- 专利标题（中）： 编码棒状杆菌细菌脱磷酸甘油酸脱氢酶的核苷酸序列和产生l-丝氨酸的方法
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申请号： US10520999申请日： 2003-07-08
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公开(公告)号： US20060106207A1公开(公告)日： 2006-05-18
- 发明人: Lothar Eggeling , Petra Peters-Wendisch , Roman Netzer , Hermann Sahm , Robert Faurie , Birgit Klassen
- 申请人： Lothar Eggeling , Petra Peters-Wendisch , Roman Netzer , Hermann Sahm , Robert Faurie , Birgit Klassen
- 专利权人： Forschungszentrum Julich GMBH
- 当前专利权人： Forschungszentrum Julich GMBH
- 优先权： DE10231297.4 20020710
- 国际申请： PCT/DE03/02290 WO 20030708
- 主分类号： C07H21/04
- IPC分类号： C07H21/04
摘要：
The invention relates to nucleotide sequences of coryneform bacteria that encode proteins that are involved in the biosynthesis of L-serine and to a method for producing L-serine. According to the invention, at least 79 amino acids at the C terminus of the wild-type serA sequence are deleted, thereby producing a 3-phosphoglycerate dehydrogenase having a reduced feedback inhibition by L-serine vis-à-vis the wild-type sequence.
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