发明申请
US20060110796A1 In vivo site-specific incorporation of N-acetyl-galactosamine amino acids in eubacteria
失效
N-乙酰半乳糖胺氨基酸在真细菌中的体内位点特异性掺入
- 专利标题: In vivo site-specific incorporation of N-acetyl-galactosamine amino acids in eubacteria
- 专利标题(中): N-乙酰半乳糖胺氨基酸在真细菌中的体内位点特异性掺入
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申请号: US11255601申请日: 2005-10-20
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公开(公告)号: US20060110796A1公开(公告)日: 2006-05-25
- 发明人: Peter Schultz , Sarah Hanson , Ran Xu , Zhiwen Zhang , Chi-Huey Wong
- 申请人: Peter Schultz , Sarah Hanson , Ran Xu , Zhiwen Zhang , Chi-Huey Wong
- 申请人地址: US CA La Jolla
- 专利权人: The Scripps Research Institute
- 当前专利权人: The Scripps Research Institute
- 当前专利权人地址: US CA La Jolla
- 主分类号: C12P21/06
- IPC分类号: C12P21/06 ; C07H21/04 ; C12P19/34 ; C12N9/22 ; C12N15/74 ; C12N1/21
摘要:
Methods and compositions for making glycoproteins, both in vitro and in vivo, are provided. One method involves incorporating an unnatural amino acid having a N-acetylgalactosamine moiety into a protein; optionally, the N-acetylgalactosamine-containing unnatural amino acid can be further modified with additional sugars.
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