发明申请
US20060116421A1 Tetrahydropyranyl cyclopentyl benzylamide modulators of chemokine receptor activity
失效
趋化因子受体活性的四氢吡喃基环戊基苄基酰胺调节剂
- 专利标题: Tetrahydropyranyl cyclopentyl benzylamide modulators of chemokine receptor activity
- 专利标题(中): 趋化因子受体活性的四氢吡喃基环戊基苄基酰胺调节剂
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申请号: US10533326申请日: 2003-10-24
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公开(公告)号: US20060116421A1公开(公告)日: 2006-06-01
- 发明人: Gabor Butora , Sander Mills , Alexander Pasternak , Kothandaraman Shankaran , Lihu Yang , Changyou Zhou , Stephen Goble
- 申请人: Gabor Butora , Sander Mills , Alexander Pasternak , Kothandaraman Shankaran , Lihu Yang , Changyou Zhou , Stephen Goble
- 国际申请: PCT/US03/33972 WO 20031024
- 主分类号: A61K31/35
- IPC分类号: A61K31/35 ; A61K31/16 ; C07D309/04
摘要:
The present invention is directed to compounds of the formula (I) (wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R27, R28, R29, R30, R31, X, m, n and the dashed line are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptor CCR-2.