发明申请
US20060134763A1 Stereoselective process for the production of dioxolane nucleoside analogues 有权
用于生产二氧戊环核苷类似物的立体选择性方法

  • 专利标题: Stereoselective process for the production of dioxolane nucleoside analogues
  • 专利标题(中): 用于生产二氧戊环核苷类似物的立体选择性方法
  • 申请号: US10535235
    申请日: 2003-11-18
  • 公开(公告)号: US20060134763A1
    公开(公告)日: 2006-06-22
  • 发明人: Alex CimpoiaJames Lalonde
  • 申请人: Alex CimpoiaJames Lalonde
  • 国际申请: PCT/CA03/01798 WO 20031118
  • 主分类号: C12P17/16
  • IPC分类号: C12P17/16 C07D473/02 C07D405/04
Stereoselective process for the production of dioxolane nucleoside analogues
摘要:
The present invention relates to a process for producing a compound of formula (I); said process comprising the steps of: a) subjecting a compound of formula (II) to an enzymatic diastereomeric resolution in the presence of a suitable amount of enzyme chosen from Pig Liver Esterase or Porcine Pancreatic Lipase b) recovering said compound of formula (I). The invention also provides a process for producing a compound of formula (III); said process comprising the steps of: a) subjecting a compounds of formula (IV) to an enzymatic diastereomeric resolution in the presence of a suitable amount of enzyme chosen from Candida Antarctica “A” lipase, Candida Antarctica “B”lipase, Candida Lypolitica Lipase or Rhizomucor Miehei Lipase b) recovering said compound of formula (III).
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