发明申请
- 专利标题： Method of producing macrolide compound
- 专利标题（中）： 大环内酯类化合物的制备方法
-
申请号： US10532412申请日： 2003-11-27
-
公开(公告)号： US20060141589A1公开(公告)日： 2006-06-29
- 发明人: Akifumi Okuda , Satoshi Yamamoto , Takashi Sakai , Susumu Takeda , Takashi Nakashima , Katsura Kaneko , Tomohiro Sameshima , Taira Kato , Naoto Kawamura
- 申请人： Akifumi Okuda , Satoshi Yamamoto , Takashi Sakai , Susumu Takeda , Takashi Nakashima , Katsura Kaneko , Tomohiro Sameshima , Taira Kato , Naoto Kawamura
- 优先权： JP2002-346796 20021129
- 国际申请： PCT/JP03/15170 WO 20031127
- 主分类号： C12P17/02
- IPC分类号： C12P17/02 ; C12N1/21
摘要：
The present invention provides a novel method of producing the 12-membered ring macrolide compound 11107D having an antitumor activity by biological transformation. Starting material which is the 12-membered ring macrolide compound 11107B represented by the formula (I) is incubated in the presence of a strain belonging to the genus Mortierella, the genus Streptomyces or the family Micromonosporaceae (for example, Streptomyces sp. AB-1704 strain (FERM BP-8551)), each of which has the ability of transforming the 12-membered ring macrolide compound 11107B into a 11107D substance represented by the formula (II), or a preparation of its cultured mycelia and oxygen, and then 11107D substance which is a target material is collected from the treating solution.
公开/授权文献
- US07745198B2 Method of producing macrolide compound 公开/授权日：2010-06-29