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    Method of producing macrolide compound
    1.
    发明授权
    Method of producing macrolide compound 失效
    大环内酯类化合物的制备方法

    公开(公告)号：US07745198B2

    公开(公告)日：2010-06-29

    申请号：US10532412

    申请日：2003-11-27

    申请人： Akifumi Okuda ,  Satoshi Yamamoto ,  Takashi Sakai ,  Susumu Takeda ,  Takashi Nakashima ,  Katsura Kaneko ,  Tomohiro Sameshima ,  Taira Kato ,  Naoto Kawamura

    发明人： Akifumi Okuda ,  Satoshi Yamamoto ,  Takashi Sakai ,  Susumu Takeda ,  Takashi Nakashima ,  Katsura Kaneko ,  Tomohiro Sameshima ,  Taira Kato ,  Naoto Kawamura

    IPC分类号： C12N1/20 ,  A01N43/02

    CPC分类号： C07D407/06 ,  A61K31/336 ,  C12P17/162

    摘要： The present invention provides a novel method of producing the 12-membered ring macrolide compound 11107D having an antitumor activity by biological transformation. Starting material which is the 12-membered ring macrolide compound 11107B represented by the formula (I) is incubated in the presence of a strain belonging to the genus Mortierella, the genus Streptomyces or the family Micromonosporaceae (for example, Streptomyces sp. AB-1704 strain (FERM BP-8551)), each of which has the ability of transforming the 12-membered ring macrolide compound 11107B into a 11107D substance represented by the formula (II), or a preparation of its cultured myceha and oxygen, and then 11107D substance which is a target material is collected from the treating solution.

    摘要翻译： 本发明提供了通过生物转化制备具有抗肿瘤活性的12元环大环内酯化合物11107D的新方法。 作为式（I）所示的12元环大环内酯化合物11107B的起始原料在属于被孢霉属（Mortierella），链霉菌属（Streptomyces）属或小单孢菌属（Micromonosporaceae）的菌株（例如，链霉菌属AB-1704 菌株（FERM BP-8551）），其各自具有将12元环大环内酯化合物11107B转化为由式（II）表示的11107D物质或其培养的肌肉和氧的制剂的能力，然后将11107D 从处理液中收集作为目标物质的物质。

    Method of producing macrolide compound
    2.
    发明申请
    Method of producing macrolide compound 失效
    大环内酯类化合物的制备方法

    公开(公告)号：US20060141589A1

    公开(公告)日：2006-06-29

    申请号：US10532412

    申请日：2003-11-27

    申请人： Akifumi Okuda ,  Satoshi Yamamoto ,  Takashi Sakai ,  Susumu Takeda ,  Takashi Nakashima ,  Katsura Kaneko ,  Tomohiro Sameshima ,  Taira Kato ,  Naoto Kawamura

    发明人： Akifumi Okuda ,  Satoshi Yamamoto ,  Takashi Sakai ,  Susumu Takeda ,  Takashi Nakashima ,  Katsura Kaneko ,  Tomohiro Sameshima ,  Taira Kato ,  Naoto Kawamura

    IPC分类号： C12P17/02 ,  C12N1/21

    CPC分类号： C07D407/06 ,  A61K31/336 ,  C12P17/162

    摘要： The present invention provides a novel method of producing the 12-membered ring macrolide compound 11107D having an antitumor activity by biological transformation. Starting material which is the 12-membered ring macrolide compound 11107B represented by the formula (I) is incubated in the presence of a strain belonging to the genus Mortierella, the genus Streptomyces or the family Micromonosporaceae (for example, Streptomyces sp. AB-1704 strain (FERM BP-8551)), each of which has the ability of transforming the 12-membered ring macrolide compound 11107B into a 11107D substance represented by the formula (II), or a preparation of its cultured mycelia and oxygen, and then 11107D substance which is a target material is collected from the treating solution.

    摘要翻译： 本发明提供了通过生物转化制备具有抗肿瘤活性的12元环大环内酯化合物11107D的新方法。 作为式（I）所示的12元环大环内酯化合物11107B的起始原料在属于被孢霉属（Mortierella），链霉菌属（Streptomyces）属或小单孢菌属（Micromonosporaceae）的菌株（例如，链霉菌属AB-1704 菌株（FERM BP-8551）），其各自具有将12元环大环内酯化合物11107B转化为由式（II）表示的11107D物质或其培养的菌丝体和氧气的制剂的能力，然后将11107D 从处理液中收集作为目标物质的物质。

    INFORMATION PROCESSING APPARATUS AND COMPUTER PROGRAM PRODUCT
    9.
    发明申请
    INFORMATION PROCESSING APPARATUS AND COMPUTER PROGRAM PRODUCT 有权
    信息处理设备和计算机程序产品

    公开(公告)号：US20120180067A1

    公开(公告)日：2012-07-12

    申请号：US13347416

    申请日：2012-01-10

    申请人： Kenji FUNAOKA ,  Nobuaki Tojo ,  Susumu Takeda ,  Akira Kuroda ,  Hidenori Matsuzaki

    发明人： Kenji FUNAOKA ,  Nobuaki Tojo ,  Susumu Takeda ,  Akira Kuroda ,  Hidenori Matsuzaki

    IPC分类号： G06F9/46

    CPC分类号： G06F8/456

    摘要： According to an embodiment, based on task border information, and first-type dependency relationship information containing N number of nodes corresponding to data accesses to one set of data, containing edges representing dependency relationship between the nodes, and having at least one node with an access reliability flag indicating reliability/unreliability of corresponding data access; task border edges, of edges extending over task borders, are identified that have an unreliable access node linked to at least one end, and presentation information containing unreliable access nodes is generated. According to dependency existence information input corresponding to the set of data, conversion information indicating absence of data access to the unreliable access nodes is output. According to the conversion information, the first-type dependency relationship information is converted into second-type dependency relationship information containing M number of nodes (0≦M≦N) corresponding to data accesses to the set of data and containing edges representing inter-node dependency relationship.

    摘要翻译： 根据实施例，基于任务边界信息和包含对应于对一组数据的数据访问的N个节点的第一类型依赖关系信息，其包含表示节点之间的依赖关系的边缘，并且具有至少一个具有 指示相应数据访问的可靠性/不可靠性的访问可靠性标志; 识别出任务边界在任务边界上延伸的边缘，其具有链接到至少一个端点的不可靠访问节点，并且生成包含不可靠访问节点的呈现信息。 根据与该组数据相对应的依赖存在信息，输出指示不存在不可靠访问节点的数据访问的转换信息。 根据转换信息，将第一类型依赖关系信息转换成与数据访问相对应的M个节点（0＆nlE; M＆nlE; N）的第二类型依赖关系信息，并且包含表示节点间的边缘 依赖关系。

    Indicator needle of automotive instrument and method of manufacturing the same
    10.
    发明授权
    Indicator needle of automotive instrument and method of manufacturing the same 失效
    汽车仪表指针及其制造方法

    公开(公告)号：US5161872A

    公开(公告)日：1992-11-10

    申请号：US800354

    申请日：1991-12-02

    申请人： Takami Sasaki ,  Hirofumi Imaizumi ,  Satoshi Yamada ,  Masahiro Yasutake ,  Susumu Takeda

    发明人： Takami Sasaki ,  Hirofumi Imaizumi ,  Satoshi Yamada ,  Masahiro Yasutake ,  Susumu Takeda

    IPC分类号： G01D13/28

    CPC分类号： G01D13/28 ,  Y10S362/80

    摘要： An indicator needle is provided with a base having a groove having a U-shaped cross section, which groove has an opening in an upper surface thereof and extends in a longitudinal direction of the indicator, and a light transmitting lens which plugs the opening of the upper surface of the base. A plurality of light emitting diodes are arranged in the groove of the base. Base ribs each having a triangular cross section and formed integrally with the base so as to cross the groove of the base are provided in the groove of the base, as well. Light generated from the light emitting diodes directly illuminates the lens, or is reflected by the base ribs to illuminates the same.

    摘要翻译： 指示针设置有具有U形横截面的凹槽的基部，该凹槽在其上表面中具有开口并沿着指示器的纵向方向延伸;以及透光透镜，其将 基座的上表面。 多个发光二极管布置在基座的凹槽中。 也可以在底座的凹槽中设置各自具有三角形横截面并且与基座一体形成以跨过基部的凹槽的基座肋。 从发光二极管产生的光直接照亮透镜，或被基座肋条反射以照亮透镜。