发明申请
US20060148023A1 Affinity labeling of serine proteases for simultaneous detection of multiple serine protease activity levels
审中-公开
亲和标记丝氨酸蛋白酶同时检测多个丝氨酸蛋白酶活性水平
- 专利标题： Affinity labeling of serine proteases for simultaneous detection of multiple serine protease activity levels
- 专利标题（中）： 亲和标记丝氨酸蛋白酶同时检测多个丝氨酸蛋白酶活性水平
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申请号： US10872824申请日： 2004-06-21
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公开(公告)号： US20060148023A1公开(公告)日： 2006-07-06
- 发明人: David Phelps , Gary Johnson , Brian Lee , Zbigniew Darzynkiewicz , Jerzy Grabarek
- 申请人： David Phelps , Gary Johnson , Brian Lee , Zbigniew Darzynkiewicz , Jerzy Grabarek
- 主分类号： C12Q1/37
- IPC分类号： C12Q1/37
摘要：
The invention provides assay methods and reagents useful for evaluating the level of enzyme activities within living cells. Enzyme activity levels within living cells, such as Serine proteases, can be key determinates in assessing; 1) the presence of tumor (cancer) cells, 2) the predictive efficacy of a chemotherapeutic treatment regimen using a particular therapeutic agent or process, 4) the probability of graft rejection or acceptance, and 5) the disease state status of a cell. The identification of the up or down regulation relationships of serine proteases within living cell systems, provides a rapid, yet finely tuned mechanism for predicting the current and future physiological state of these cell populations.
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