发明申请
US20060159619A1 Cell permeable nanoconjugates of shell-crosslinked knedel (SCK) and peptide nucleic acids ("PNAs") with uniquely expressed or over-expressed mRNA targeting sequences for early diagnosis and therapy of cancer
有权
具有独特表达或过表达的mRNA靶向序列的壳交联睾丸（SCK）和肽核酸（“PNA”）的细胞可渗透纳米缀合物用于癌症的早期诊断和治疗
- 专利标题： Cell permeable nanoconjugates of shell-crosslinked knedel (SCK) and peptide nucleic acids ("PNAs") with uniquely expressed or over-expressed mRNA targeting sequences for early diagnosis and therapy of cancer
- 专利标题（中）： 具有独特表达或过表达的mRNA靶向序列的壳交联睾丸（SCK）和肽核酸（“PNA”）的细胞可渗透纳米缀合物用于癌症的早期诊断和治疗
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申请号： US11250830申请日： 2005-10-14
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公开(公告)号： US20060159619A1公开(公告)日： 2006-07-20
- 发明人: Matthew Becker , Huafeng Fang , Xiaoxu Li , Dipanjan Pan , Raffaella Rossin , Xiankai Sun , John-Stephen Taylor , Jeffrey Turner , Michael Welch , Karen Wooley
- 申请人： Matthew Becker , Huafeng Fang , Xiaoxu Li , Dipanjan Pan , Raffaella Rossin , Xiankai Sun , John-Stephen Taylor , Jeffrey Turner , Michael Welch , Karen Wooley
- 主分类号： A61K51/00
- IPC分类号： A61K51/00 ; C12Q1/68 ; A61K48/00
摘要：
A functional biologically active particle conjugate useful for diagnosis and treating cancer as a bioportal comprises a nanoscale particle having associated therewith an intracellular targeting ligand comprising a PNA, or another nuclease resistant oligonucleotide analog such as MOE-mRNA (2′-methoxyethyl mRNA) or LNA (locked nucleic acid), having a sequence that binds selectively to an uniquely expressed or overexpressed mRNA specific to the cancer or disease state in a living mammal. In one aspect the uniquely overexpressed target specific to the cancer or disease state is the unr mRNA which can be targeted by the antisense sequence PNA50.
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