发明申请
- 专利标题： Transcriptional factor inducing apoptosis in cancer cell
- 专利标题（中）： 转录因子诱导癌细胞凋亡
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申请号： US10546829申请日： 2004-02-25
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公开(公告)号： US20060159692A1公开(公告)日： 2006-07-20
- 发明人: Yoichi Taya , Masato Enari
- 申请人： Yoichi Taya , Masato Enari
- 优先权： JP2003-04858 20030226
- 国际申请： PCT/JP04/02238 WO 20040225
- 主分类号： C12N9/99
- IPC分类号： C12N9/99 ; A61K39/00
摘要：
A new method for treating cancer by inducing apoptosis exclusively in cancer cells and killing them is provided. The present invention relates to a transcriptional factor, comprising p53 or a mutated type p53, wherein one or more amino acids are deleted, substituted or added with respect to the amino sequence of p53, and clathrin heavy chains and having an activity to induce apoptosis of cancer cells. The transcriptional factor enhances the transcriptional activity of p53AIP1 promoter and induces apoptosis of cancer cells.
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