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公开(公告)号：US20080108085A1
公开(公告)日：2008-05-08
申请号：US11697351
申请日：2007-04-06
CPC分类号： G01N33/553 , G01N33/6896 , G01N2800/2828
摘要： The invention relates to methods for determining the presence of prions in a tissue/organ or fluid therefrom; said method comprising the steps of: contacting the tissue/organ with one or more devices, wherein said devices are capable of binding prions; removing said devices from contact with said tissue/organ; determining if said devices are binding prions wherein the device is contacted with the tissue/organ for 120 minutes.
摘要翻译： 本发明涉及用于确定在其中的组织/器官或流体中存在朊病毒的方法; 所述方法包括以下步骤：使组织/器官与一种或多种装置接触，其中所述装置能够结合朊病毒; 去除所述装置与所述组织/器官的接触; 确定所述装置是否是结合性朊病毒，其中装置与组织/器官接触120分钟。
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公开(公告)号：US20060159692A1
公开(公告)日：2006-07-20
申请号：US10546829
申请日：2004-02-25
申请人： Yoichi Taya , Masato Enari
发明人： Yoichi Taya , Masato Enari
CPC分类号： C07K14/4702 , A61K38/1709 , C07K14/4746
摘要： A new method for treating cancer by inducing apoptosis exclusively in cancer cells and killing them is provided. The present invention relates to a transcriptional factor, comprising p53 or a mutated type p53, wherein one or more amino acids are deleted, substituted or added with respect to the amino sequence of p53, and clathrin heavy chains and having an activity to induce apoptosis of cancer cells. The transcriptional factor enhances the transcriptional activity of p53AIP1 promoter and induces apoptosis of cancer cells.
摘要翻译： 提供了一种通过仅在癌细胞中诱导凋亡并杀死癌症来治疗癌症的新方法。 本发明涉及包含p53或突变型p53的转录因子，其中相对于p53的氨基酸序列缺失，取代或添加一个或多个氨基酸，并且具有诱导细胞凋亡的活性的网格蛋白重链 癌细胞。 转录因子增强p53AIP1启动子的转录活性，诱导癌细胞凋亡。
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公开(公告)号：US20050221320A1
公开(公告)日：2005-10-06
申请号：US10508236
申请日：2003-03-20
CPC分类号： G01N33/5091 , G01N33/6893 , G01N2800/2828
摘要： The present invention relates to a method for detecting a prion in a sample comprising providing a population of cells which are susceptible to prion infection, contacting the population of cells with the cells with the sample, incubating the cells on a growth substrate, assaying for prion colony formation wherein presence of prion colonies indicates presence of prions in the sample. The invention further relates to methods for quantifying the prions, and to cell lines sensitive to prion infection.
摘要翻译： 本发明涉及一种检测样品中朊病毒的方法，包括提供易受朊病毒感染影响的细胞群，将细胞群与细胞接触样品，将细胞孵育在生长底物上，测定朊病毒 集落形成，其中存在朊病毒集落表明样品中存在朊病毒。 本发明还涉及用于量化朊病毒的方法和对朊病毒感染敏感的细胞系。
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