发明申请
US20060167033A1 7-Imino derivatives of camptothecin having antitumor activity
有权
具有抗肿瘤活性的喜树碱的7-亚氨基衍生物
- 专利标题： 7-Imino derivatives of camptothecin having antitumor activity
- 专利标题（中）： 具有抗肿瘤活性的喜树碱的7-亚氨基衍生物
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申请号： US10546211申请日： 2004-03-10
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公开(公告)号： US20060167033A1公开(公告)日： 2006-07-27
- 发明人: Sabrina Dallavalle , Sergio Penco , Claudio Pisano , Franco Zunino
- 申请人： Sabrina Dallavalle , Sergio Penco , Claudio Pisano , Franco Zunino
- 优先权： US10388587 20030317
- 国际申请： PCT/IT04/00118 WO 20040310
- 主分类号： A61K31/4745
- IPC分类号： A61K31/4745 ; C07D519/04
摘要：
Camptothecin derivatives of camptothecin of formula (I) wherein the groups R1, R2 and R3 are as defined in the description are disclosed. The compounds of formula (I) are endowed with antitumor activity and show a good therapeutic index. Processes for the preparation of the compounds of formula (I) and their use in the preparation of medicaments useful in the treatment of tumors, viral infections and antiplasmodium falciparum are also disclosed.
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