Invention Application
- Patent Title: Colored buffer solution for automated clinical analyzer
- Patent Title (中): 彩色缓冲溶液,用于自动临床分析仪
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Application No.: US11048601Application Date: 2005-02-01
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Publication No.: US20060172425A1Publication Date: 2006-08-03
- Inventor: Ralf Neigl , Michael Sommer , Bronislaw Czech , Horst Berneth , Alan Toth , Josef-Walter Stawitz
- Applicant: Ralf Neigl , Michael Sommer , Bronislaw Czech , Horst Berneth , Alan Toth , Josef-Walter Stawitz
- Applicant Address: US NY Tarrytown
- Assignee: BAYER HEALTHCARE, LLC
- Current Assignee: BAYER HEALTHCARE, LLC
- Current Assignee Address: US NY Tarrytown
- Main IPC: G01N33/00
- IPC: G01N33/00

Abstract:
A colored intercapsular buffer solution is used to reduce erroneous results from the absorption or carryover of small amounts of reagent R1 and/or R2 into the intercapsular buffer solution segment in the analytical line of a capsule chemistry liquid analysis system in an automated clinical analyzer. The absorption of small amounts of the regent R1 and/or R2 in the intercapsular buffer solution leads to erroneous results in the analysis of the test sample, S, because the R1 and/or R2 that is carried over and absorbed into the buffer does not react with test sample S. The R1/R2 carryover can be measured and determined by monitoring the absorbance of the colored buffer solution, wherein the change in absorbance can be measured and compared to a reference value. The sample is automatically retested if an unacceptable change in absorbance occurs. The colored buffer solution comprises a phthalocyanine dye, an aqueous solution of a base at a pH of about 9-12, a surfactant to reduce surface tension and improve flow characteristics of the intercapsular colored buffer reagent through the analytical line, and a chelating agent to reduce the adverse effects of metal contaminants.
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