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    Colored buffer solution for automated clinical analyzer
    3.
    发明申请
    Colored buffer solution for automated clinical analyzer 审中-公开
    彩色缓冲溶液，用于自动临床分析仪

    公开(公告)号：US20060172425A1

    公开(公告)日：2006-08-03

    申请号：US11048601

    申请日：2005-02-01

    申请人： Ralf Neigl ,  Michael Sommer ,  Bronislaw Czech ,  Horst Berneth ,  Alan Toth ,  Josef-Walter Stawitz

    发明人： Ralf Neigl ,  Michael Sommer ,  Bronislaw Czech ,  Horst Berneth ,  Alan Toth ,  Josef-Walter Stawitz

    IPC分类号： G01N33/00

    CPC分类号： G01N35/08 ,  G01N21/05 ,  G01N21/80 ,  G01N2021/0346 ,  G01N2035/00277 ,  Y10T436/108331

    摘要： A colored intercapsular buffer solution is used to reduce erroneous results from the absorption or carryover of small amounts of reagent R1 and/or R2 into the intercapsular buffer solution segment in the analytical line of a capsule chemistry liquid analysis system in an automated clinical analyzer. The absorption of small amounts of the regent R1 and/or R2 in the intercapsular buffer solution leads to erroneous results in the analysis of the test sample, S, because the R1 and/or R2 that is carried over and absorbed into the buffer does not react with test sample S. The R1/R2 carryover can be measured and determined by monitoring the absorbance of the colored buffer solution, wherein the change in absorbance can be measured and compared to a reference value. The sample is automatically retested if an unacceptable change in absorbance occurs. The colored buffer solution comprises a phthalocyanine dye, an aqueous solution of a base at a pH of about 9-12, a surfactant to reduce surface tension and improve flow characteristics of the intercapsular colored buffer reagent through the analytical line, and a chelating agent to reduce the adverse effects of metal contaminants.

    摘要翻译： 使用有色的胶囊缓冲溶液来减少在自动化临床分析仪中胶囊化学液体分析系统的分析线中的少量试剂R1和/或R2吸收或携带到胶囊缓冲溶液段中的错误结果。 在胶囊缓冲液溶液中少量摄取R1和/或R2的吸收导致对测试样品S的分析的错误结果，因为携带并吸收到缓冲液中的R1和/或R2不是 与测试样品S反应。可以通过监测着色缓冲溶液的吸光度来测量和确定R1 / R2携带量，其中可以测量吸光度的变化并与参考值进行比较。 如果吸光度发生不可接受的变化，样品将自动重新测试。 有色缓冲溶液包含酞菁染料，pH为约9-12的碱的水溶液，降低表面张力的表面活性剂，并通过分析线改善层间彩色缓冲剂的流动特性，以及螯合剂 减少金属污染物的不利影响。