发明申请
US20060183199A1 Novel expression vectors containing accessory molecule ligand genes and their use for immunomodulation and treatment of malignancies and autoimmune disease
有权
含有辅助分子配体基因的新型表达载体及其用于免疫调节和治疗恶性肿瘤和自身免疫性疾病的用途
- 专利标题： Novel expression vectors containing accessory molecule ligand genes and their use for immunomodulation and treatment of malignancies and autoimmune disease
- 专利标题（中）： 含有辅助分子配体基因的新型表达载体及其用于免疫调节和治疗恶性肿瘤和自身免疫性疾病的用途
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申请号： US11015117申请日： 2004-12-17
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公开(公告)号： US20060183199A1公开(公告)日： 2006-08-17
- 发明人: Thomas Kipps , Sanjai Sharma , Mark Cantwell
- 申请人： Thomas Kipps , Sanjai Sharma , Mark Cantwell
- 专利权人： Regents of the University of California
- 当前专利权人： Regents of the University of California
- 主分类号： C07H21/04
- IPC分类号： C07H21/04 ; C12P21/02 ; C07K14/525
摘要：
This invention relates to genes which encode accessory molecule ligands and their use for immunomodulation, vaccination and treatments of various human diseases, including malignancies and autoimmune diseases. This invention also describes the use of accessory molecule ligands which are made up of various domains and subdomain portions of molecules derived from the tumor necrosis factor family. The chimeric molecules of this invention contain unique properties which lead to the stabilization of their activities and thus greater usefulness in the treatment of diseases. Vectors for expressing genes which encode the accessory molecule ligands of this invention are also disclosed.
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