公开(公告)号：US20060183199A1

公开(公告)日：2006-08-17

申请号：US11015117

申请日：2004-12-17

申请人： Thomas Kipps ,  Sanjai Sharma ,  Mark Cantwell

发明人： Thomas Kipps ,  Sanjai Sharma ,  Mark Cantwell

IPC分类号： C07H21/04 ,  C12P21/02 ,  C07K14/525

CPC分类号： C07K14/48 ,  A61K48/00 ,  A61K2039/51 ,  C07K14/52 ,  C07K14/525 ,  C07K14/5255 ,  C07K14/705 ,  C07K14/70575 ,  C07K2319/00 ,  C12N2799/021

摘要： This invention relates to genes which encode accessory molecule ligands and their use for immunomodulation, vaccination and treatments of various human diseases, including malignancies and autoimmune diseases. This invention also describes the use of accessory molecule ligands which are made up of various domains and subdomain portions of molecules derived from the tumor necrosis factor family. The chimeric molecules of this invention contain unique properties which lead to the stabilization of their activities and thus greater usefulness in the treatment of diseases. Vectors for expressing genes which encode the accessory molecule ligands of this invention are also disclosed.

摘要翻译： 本发明涉及编码辅助分子配体的基因及其用于免疫调节，疫苗接种和治疗各种人类疾病（包括恶性肿瘤和自身免疫性疾病）的用途。 本发明还描述了由衍生自肿瘤坏死因子家族的分子的各种结构域和亚结构域部分构成的辅助分子配体的用途。 本发明的嵌合分子含有独特的性质，其导致其活性的稳定，因此在治疗疾病方面更有用。 还公开了用于表达编码本发明的辅助分子配体的基因的载体。

公开(公告)号：US20100267129A1

公开(公告)日：2010-10-21

申请号：US12371188

申请日：2009-02-13

申请人： Thomas J. Kipps ,  Sanjai Sharma ,  Mark Cantwell

发明人： Thomas J. Kipps ,  Sanjai Sharma ,  Mark Cantwell

IPC分类号： C07H21/04 ,  C07K14/435 ,  C12N5/10 ,  C12N15/63

CPC分类号： C07K14/48 ,  A61K48/00 ,  A61K2039/51 ,  C07K14/52 ,  C07K14/525 ,  C07K14/5255 ,  C07K14/705 ,  C07K14/70575 ,  C07K2319/00 ,  C12N2799/021

摘要： This invention relates to genes which encode accessory molecule ligands and their use for immunomodulation, vaccination and treatments of various human diseases, including malignancies and autoimmune diseases. This invention also describes the use of accessory molecule ligands which are made up of various domains and subdomain portions of molecules derived from the tumor necrosis factor family. The chimeric molecules of this invention contain unique properties which lead to the stabilization of their activities and thus greater usefulness in the treatment of diseases. Vectors for expressing genes which encode the accessory molecule ligands of this invention are also disclosed.

摘要翻译： 本发明涉及编码辅助分子配体的基因及其用于免疫调节，疫苗接种和治疗各种人类疾病（包括恶性肿瘤和自身免疫性疾病）的用途。 本发明还描述了由衍生自肿瘤坏死因子家族的分子的各种结构域和亚结构域部分构成的辅助分子配体的用途。 本发明的嵌合分子含有独特的性质，其导致其活性的稳定，因此在治疗疾病方面更有用。 还公开了用于表达编码本发明的辅助分子配体的基因的载体。

公开(公告)号：US07524944B2

公开(公告)日：2009-04-28

申请号：US11015117

申请日：2004-12-17

申请人： Thomas J. Kipps ,  Sanjai Sharma ,  Mark Cantwell

发明人： Thomas J. Kipps ,  Sanjai Sharma ,  Mark Cantwell

IPC分类号： C12N15/62 ,  C12N15/12 ,  C12N15/00 ,  C12N15/63

CPC分类号： C07K14/48 ,  A61K48/00 ,  A61K2039/51 ,  C07K14/52 ,  C07K14/525 ,  C07K14/5255 ,  C07K14/705 ,  C07K14/70575 ,  C07K2319/00 ,  C12N2799/021

摘要： This invention relates to genes which encode accessory molecule ligands and their use for immunomodulation, vaccination and treatments of various human diseases, including malignancies and autoimmune diseases. This invention also describes the use of accessory molecule ligands which are made up of various domains and subdomain portions of molecules derived from the tumor necrosis factor family. The chimeric molecules of this invention contain unique properties which lead to the stabilization of their activities and thus greater usefulness in the treatment of diseases. Vectors for expressing genes which encode the accessory molecule ligands of this invention are also disclosed.

摘要翻译： 本发明涉及编码辅助分子配体的基因及其用于免疫调节，疫苗接种和治疗各种人类疾病（包括恶性肿瘤和自身免疫性疾病）的用途。 本发明还描述了由衍生自肿瘤坏死因子家族的分子的各种结构域和亚结构域部分构成的辅助分子配体的用途。 本发明的嵌合分子含有独特的性质，其导致其活性的稳定，因此在治疗疾病方面更有用。 还公开了用于表达编码本发明的辅助分子配体的基因的载体。

公开(公告)号：US07906638B2

公开(公告)日：2011-03-15

申请号：US12371188

申请日：2009-02-13

申请人： Thomas J. Kipps ,  Sanjai Sharma ,  Mark Cantwell

发明人： Thomas J. Kipps ,  Sanjai Sharma ,  Mark Cantwell

IPC分类号： C12N15/62 ,  C12N15/12 ,  C12N15/00 ,  C12N15/63

CPC分类号： C07K14/48 ,  A61K48/00 ,  A61K2039/51 ,  C07K14/52 ,  C07K14/525 ,  C07K14/5255 ,  C07K14/705 ,  C07K14/70575 ,  C07K2319/00 ,  C12N2799/021

摘要： This invention relates to genes which encode accessory molecule ligands and their use for immunomodulation, vaccination and treatments of various human diseases, including malignancies and autoimmune diseases. This invention also describes the use of accessory molecule ligands which are made up of various domains and subdomain portions of molecules derived from the tumor necrosis factor family. The chimeric molecules of this invention contain unique properties which lead to the stabilization of their activities and thus greater usefulness in the treatment of diseases. Vectors for expressing genes which encode the accessory molecule ligands of this invention are also disclosed.

摘要翻译： 本发明涉及编码辅助分子配体的基因及其用于免疫调节，疫苗接种和治疗各种人类疾病（包括恶性肿瘤和自身免疫性疾病）的用途。 本发明还描述了由衍生自肿瘤坏死因子家族的分子的各种结构域和亚结构域部分构成的辅助分子配体的用途。 本发明的嵌合分子含有独特的性质，其导致其活性的稳定，因此在治疗疾病方面更有用。 还公开了用于表达编码本发明的辅助分子配体的基因的载体。

公开(公告)号：US07070771B1

公开(公告)日：2006-07-04

申请号：US08982272

申请日：1997-12-01

申请人： Thomas J. Kipps ,  Sanjai Sharma ,  Mark Cantwell

发明人： Thomas J. Kipps ,  Sanjai Sharma ,  Mark Cantwell

IPC分类号： A61K48/00 ,  C12N15/87 ,  C07H21/04

CPC分类号： C07K14/48 ,  A61K48/00 ,  A61K2039/51 ,  C07K14/52 ,  C07K14/525 ,  C07K14/5255 ,  C07K14/705 ,  C07K14/70575 ,  C07K2319/00 ,  C12N2799/021

摘要： This invention relates to genes which encode accessory molecule ligands, such as the CD40 ligand and their use for immunomodulation, vaccination and treatments of various human diseases, including malignancies and autoimmune diseases. This invention also describes the use of accessory molecule ligands which are made up of various domains and subdomain portions of molecules derived from the tumor necrosis factor family. The chimeric molecules of this invention contain unique properties which lead to the stabilization of their activities and thus greater usefulness in the treatment of diseases. Vectors for expressing genes which encode the accessory molecule ligands of this invention are also disclosed.

摘要翻译： 本发明涉及编码辅助分子配体的基因，例如CD40配体及其用于免疫调节，疫苗接种和治疗各种人类疾病（包括恶性肿瘤和自身免疫性疾病）的用途。 本发明还描述了由衍生自肿瘤坏死因子家族的分子的各种结构域和亚结构域部分构成的辅助分子配体的用途。 本发明的嵌合分子含有独特的性质，其导致其活性的稳定，因此在治疗疾病方面更有用。 还公开了用于表达编码本发明的辅助分子配体的基因的载体。

公开(公告)号：US20050048476A1

公开(公告)日：2005-03-03

申请号：US10006305

申请日：2001-12-06

申请人： Charles Prussak ,  Thomas Kipps ,  Mark Cantwell

发明人： Charles Prussak ,  Thomas Kipps ,  Mark Cantwell

IPC分类号： C12N15/09 ,  A61K31/7088 ,  A61K38/00 ,  A61K48/00 ,  A61P35/00 ,  C07K14/525 ,  C07K19/00 ,  C12N5/10 ,  C12P21/02 ,  C12P21/04 ,  C12Q1/68 ,  C07H21/04 ,  C07K14/52 ,  C12N5/06

CPC分类号： C07K14/525 ,  A61K38/00 ,  C07K2319/00

摘要： The present invention is directed to an isolated polynucleotide sequence encoding a chimeric TNFα, comprising a first nucleotide sequence encoding a domain or subdomain of a tumor necrosis factor ligand other than TNFα, wherein the encoded domain or subdomain replaces a cleavage site of native TNFα, and a second nucleotide sequence encoding a domain or subdomain of native TNFα that binds to a TNFα receptor. The encoded chimeric TNFα is significantly less susceptible to cleavage from the cellular surface and, as a result can increase the concentration of a ligand capable of binding to a TNFα receptor on the surface of a cell. The chimeric TNFα is therefore useful in methods for inducing apoptosis of a cell expressing a TNFα receptor, inducing activation of an immune system cell and treating neoplastic cells, by introducing into the cell of interest an isolated polynucleotide sequence encoding a chimeric TNFα that is expressed on the surface of the cell.

摘要翻译： 本发明涉及编码嵌合TNFα的分离的多核苷酸序列，其包含编码除TNFalpha之外的肿瘤坏死因子配体的结构域或亚结构域的第一核苷酸序列，其中编码的结构域或亚结构域替代天然TNFα的切割位点，以及 编码结合TNFα受体的天然TNFα的结构域或亚结构域的第二核苷酸序列。 编码的嵌合TNFα对于细胞表面的切割显着较不敏感，因此可以增加能够结合细胞表面的TNFα受体的配体的浓度。 因此，嵌合TNFα可用于诱导表达TNFα受体的细胞凋亡的方法，诱导免疫系统细胞的活化和治疗肿瘤细胞，通过将感兴趣的细胞引入编码嵌合TNFα的分离的多核苷酸序列，所述多核苷酸序列表达于 电池的表面。

公开(公告)号：US20070280944A1

公开(公告)日：2007-12-06

申请号：US10594850

申请日：2005-04-01

申请人： Joan Robbins ,  Mark Cantwell

发明人： Joan Robbins ,  Mark Cantwell

IPC分类号： A61K39/395 ,  A61K31/525 ,  A61K31/7072 ,  A61K31/704 ,  A61K31/4745 ,  A61K31/337

CPC分类号： A61K45/06 ,  A61K31/505 ,  A61K39/395 ,  A61K2300/00

摘要： The present invention provides novel uses and compositions for 5,10-methylene tetrahydrofolate (“5,10-CH2-THFA”) in the treatment of cancer. The present invention is based on the surprising result that 5,10-CH2-THFA, while increasing the efficacy of 5-fluoruracil (5-FU) in reducing the rate of tumor growth and increasing survivorship, also reduces the toxicity to the patient of 5-FU. The present invention provides methods and compositions for treating cancer patients that include 5-FU, 5,10-CH2-THFA, and one or more additional anticancer drugs. Such methods and compositions can provide increased efficacy and reduced toxicity when compared with current treatment modalities.

摘要翻译： 本发明提供了用于治疗癌症的5,10-亚甲基四氢叶酸（“5,10-CH 2 -THFA”）的新用途和组合物。 本发明基于令人惊奇的结果，即5,10-CH 2 -THFA，同时提高5-氟尿嘧啶（5-FU）在降低肿瘤生长速率和增加存活率方面的功效， 也降低对5-FU患者的毒性。 本发明提供了治疗癌症患者的方法和组合物，其包括5-FU，5,10-CH 2 -THFA和一种或多种另外的抗癌药物。 与目前的治疗方式相比，这些方法和组合物可提供更高的疗效和降低的毒性。