发明申请
- 专利标题： TNF-a production inhibitors
- 专利标题（中）： TNF-α产生抑制剂
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申请号： US11448634申请日： 2006-06-07
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公开(公告)号： US20060229342A1公开(公告)日： 2006-10-12
- 发明人: Masakazu Ban , Hiroshi Suhara , Masato Horiuchi , Noriyoshi Yamamoto , Hiroshi Enomoto , Hiroyuki Inoue
- 申请人： Masakazu Ban , Hiroshi Suhara , Masato Horiuchi , Noriyoshi Yamamoto , Hiroshi Enomoto , Hiroyuki Inoue
- 申请人地址： JP Osaka-shi
- 专利权人： SANTEN PHARMACEUTICAL, CO., LTD.
- 当前专利权人： SANTEN PHARMACEUTICAL, CO., LTD.
- 当前专利权人地址： JP Osaka-shi
- 优先权： JP2000-162945 20000531
- 主分类号： C07D213/06
- IPC分类号： C07D213/06 ; A61K31/44
摘要：
A purpose of the present invention is to provide TNF-α production inhibitors being useful as therapeutic agents for autoimmune diseases such as rheumatoid arthritis. Novel compounds having the structure represented by the general formula [1] or salts thereof according to the present invention have excellent TNF-α production inhibitory activities, wherein “A” is —(NR4)—, —(CR5R6)— or —O—, “B” is alkylene or alkenylene, R1, R2, R4, R5 and R6 are hydrogen, alkyl, alkenyl, adamantyl or the like, R3 is aryl or an unsaturated heterocycle, and “X” is oxygen or sulfer respectively.
公开/授权文献
- US07491739B2 TNF-α production inhibitors 公开/授权日：2009-02-17
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