公开(公告)号：US20120202817A1

公开(公告)日：2012-08-09

申请号：US13449921

申请日：2012-04-18

申请人： Takahiro Honda ,  Hisashi Tajima ,  Yoshimasa Sasabuchi ,  Kenji Kawashima ,  Kazuyoshi Okamoto ,  Minoru Yamamoto ,  Masakazu Ban

发明人： Takahiro Honda ,  Hisashi Tajima ,  Yoshimasa Sasabuchi ,  Kenji Kawashima ,  Kazuyoshi Okamoto ,  Minoru Yamamoto ,  Masakazu Ban

IPC分类号： A61K31/4409 ,  C07D409/12 ,  A61K31/4436 ,  C07D401/12 ,  A61K31/4709 ,  C07D413/14 ,  A61K31/5377 ,  C07D409/14 ,  A61K31/4545 ,  A61K31/4439 ,  C07D405/12 ,  A61K31/443 ,  A61P35/00 ,  A61P29/00 ,  A61P27/02 ,  A61P17/06 ,  A61P9/10 ,  C07D213/56

CPC分类号： C07D401/12 ,  C07D213/32 ,  C07D401/14

摘要： A compound having the following formula [I] or a pharmaceutically acceptable salt thereof: wherein A is an aromatic five-membered heterocycle which optionally is fused with a cycloalkane ring; B is an alkylene; R1 and R2 are hydrogen, hydroxyl, alkoxy, aryloxy, alkyl, cycloalkyl, aryl, heterocycle, amino, alkylamino, arylamino or acyl, or R1 and R2 join together to form a heterocycle; X and Y are hydrogen, halogen, hydroxyl, alkoxy, aryloxy, alkyl, cycloalkyl, aryl, mercapto, alkylthio, arylthio, carboxyl, an ester of carboxyl, an amide of carboxyl, cyano or nitro; p is 0, 1 or 2; and q is 0 or 1. The compound is useful for treating diseases in which angiogenesis or augmentation of vascular permeability is involved.

摘要翻译： 具有下式[I]的化合物或其药学上可接受的盐：其中A是任选与环烷烃环稠合的芳族五元杂环; B是亚烷基; R 1和R 2是氢，羟基，烷氧基，芳氧基，烷基，环烷基，芳基，杂环，氨基，烷基氨基，芳基氨基或酰基，或R 1和R 2连接在一起形成杂环; X和Y是氢，卤素，羟基，烷氧基，芳氧基，烷基，环烷基，芳基，巯基，烷硫基，芳硫基，羧基，羧基的酯，羧基的酰胺，氰基或硝基; p为0,1或2; q为0或1.该化合物可用于治疗涉及血管生成或增加血管通透性的疾病。

公开(公告)号：US20110265952A1

公开(公告)日：2011-11-03

申请号：US13182204

申请日：2011-07-13

申请人： Sunao MURAOKA ,  Hideki Nagaoka ,  Masakazu Ban ,  Cai Zhong Tian

发明人： Sunao MURAOKA ,  Hideki Nagaoka ,  Masakazu Ban ,  Cai Zhong Tian

IPC分类号： H01L21/3065 ,  F16K3/00

CPC分类号： H01J37/32192 ,  H01J37/32275 ,  H01J2237/0206

摘要： A gate valve includes a plate-shaped valve element which is rectangular-shaped to suit the shape of an opening of a processing chamber and has a size larger than the opening. A hermetically sealing member to perform hermetic sealing by abutting on and being pressed against an outer side of the processing chamber is provided in the valve element. A microwave reflecting mechanism which is formed in a groove shape so as to surround a periphery of the hermetically sealing member is provided at an outer peripheral portion of the hermetically sealing member.

摘要翻译： 闸阀包括板形阀元件，其为矩形以适合处理室的开口的形状并且具有大于开口的尺寸。 在阀元件中设置有通过抵靠处理室的外侧并且被压靠在处理室的外侧来进行气密密封的气密密封构件。 在气密密封部件的外周部设置微波反射机构，其形成为围绕密封部件周围的槽状。

公开(公告)号：US07098226B2

公开(公告)日：2006-08-29

申请号：US10168777

申请日：2001-05-31

申请人： Masakazu Ban ,  Hiroshi Suhara ,  Masato Horiuchi ,  Noriyoshi Yamamoto ,  Hiroshi Enomoto ,  Hiroyuki Inoue

发明人： Masakazu Ban ,  Hiroshi Suhara ,  Masato Horiuchi ,  Noriyoshi Yamamoto ,  Hiroshi Enomoto ,  Hiroyuki Inoue

IPC分类号： A61K31/44 ,  C07D213/06

CPC分类号： C07D213/56 ,  C07D213/30 ,  C07D213/32 ,  C07D213/38 ,  C07D213/40 ,  C07D213/68 ,  C07D213/75 ,  C07D401/06

摘要： A purpose of the present invention is to provide TNF-α production inhibitors being useful as therapeutic agents for autoimmune diseases such as rheumatoid arthritis. Novel compounds having the structure represented by the general formula [1] or salts thereof according to the present invention have excellent TNF-α production inhibitory activities, wherein “A” is —(NR4)—, —(CR5R6)— or —O—, “B” is alkylene or alkenylene, R1, R2, R4, R5 and R6 are hydrogen, alkyl, alkenyl, adamantyl or the like, R3 is aryl or an unsaturated heterocycle, and “X” is oxygen or sulfer respectively.

摘要翻译： 本发明的目的是提供TNF-α产生抑制剂，其可用作自身免疫疾病如类风湿性关节炎的治疗剂。 具有本发明的通式[1]所示结构或其盐的新化合物具有优异的TNF-α产生抑制活性，其中“A”为 - （NR 4 - ） - ， - （CR 5）6 - 或-O-，“B”是亚烷基或亚烯基，R 1，R 2， R 4，R 5，R 6和R 6是氢，烷基，烯基，金刚烷基等，R 3 芳基或不饱和杂环，“X”分别是氧或硫。

公开(公告)号：US06683200B2

公开(公告)日：2004-01-27

申请号：US09969971

申请日：2001-10-04

申请人： Shiro Mita ,  Masato Horiuchi ,  Masakazu Ban ,  Hiroshi Suhara

发明人： Shiro Mita ,  Masato Horiuchi ,  Masakazu Ban ,  Hiroshi Suhara

IPC分类号： C07C32344

CPC分类号： C07C323/44 ,  A61K31/17 ,  C07C275/14 ,  C07C275/18 ,  C07C275/24 ,  C07C327/06 ,  C07C2601/14

摘要： N-Substituted-N′-substituted urea derivatives represented by the following formula, analogs thereof or pharmaceutically acceptable salts thereof are herein provided. These compounds show a TNF-&agr; production inhibitory activity.

摘要翻译： 本文提供了由下式表示的N-取代的N'-取代的脲衍生物，其类似物或其药学上可接受的盐。 这些化合物显示TNF-α产生抑制活性。

公开(公告)号：US6034283A

公开(公告)日：2000-03-07

申请号：US111890

申请日：1998-07-08

申请人： Masakazu Ban ,  Mineyuki Iwasaki

发明人： Masakazu Ban ,  Mineyuki Iwasaki

IPC分类号： C07C29/04 ,  C07C29/20

CPC分类号： C07C29/04 ,  C07C2101/14 ,  Y02P20/582

摘要： A process for producing a cyclic alcohol by a catalytic hydration reaction of a starting cyclic olefin represented by the following formula (1) and water:C.sub.s H.sub.2s-2-t R.sub.t (1)wherein R is a hydrogen atom, an alkyl group having 1 to 4 carbon atoms, a phenyl group or a cyclohexyl group; s is an integer of 5 to 12; and t is an integer of 1 to 4, which comprises supplying a part or the whole of a residue left after separation of said cyclic alcohol from an oil phase containing said cyclic alcohol, unreacted cyclic olefin and impurities having a boiling point between the boiling point of said starting cyclic olefin and that of said cyclic alcohol to a distillation column(s), and recycling the unreacted cyclic olefin obtained after removal of said impurities.

摘要翻译： 由下式（1）表示的起始环状烯烃与水：CsH2s-2-tRt（1）的催化水合反应制备环状醇的方法其中R为氢原子，具有1-4个碳原子的烷基 碳原子，苯基或环己基; s为5〜12的整数; t为1〜4的整数，其包括将所述环状醇从含有所述环状醇的油相中分离出的残留物的一部分或全部，未反应的环状烯烃和沸点在沸点之间的沸点 的所述起始环烯烃和所述环状醇的馏分与蒸馏塔反应，并且将除去所述杂质后得到的未反应的环状烯烃进行再循环。

公开(公告)号：US4729995A

公开(公告)日：1988-03-08

申请号：US033734

申请日：1987-04-03

申请人： Hiroaki Taguchi ,  Takeo Katsushima ,  Masakazu Ban ,  Shoichi Aoki ,  Akihiko Watanabe

发明人： Hiroaki Taguchi ,  Takeo Katsushima ,  Masakazu Ban ,  Shoichi Aoki ,  Akihiko Watanabe

IPC分类号： C07D239/48 ,  C07D239/50 ,  A61K31/505 ,  A61K31/535 ,  C07D413/04

CPC分类号： C07D239/48 ,  C07D239/50

摘要： Novel pyrimidine compounds of the formula: ##STR1## wherein R.sub.1 and R.sub.1 ' are each hydrogen atom, a lower alkyl, benzyl, an alkali metal, or ammonium; R.sub.2 is hydrogen atom, a halogen atom, a lower alkyl, a lower alkoxy, an aryl, a group of the formula: ##STR2## (wherein R.sub.3 and R.sub.4 are each hydrogen atom, a lower alkyl, or an aryl), or a group of the formula: ##STR3## [wherein R.sub.5 and R.sub.6 are each an alkylene having 1 to 3 carbon atoms, and X is oxygen atom, methylene, or a group of the formula: >N-Y (wherein Y is hydrogen atom, a lower alkyl, benzyl, or an aryl)], which have excellent antiallergic activities and are useful for the prophylaxis and treatment of various allergic diseases, and a pharmaceutical composition containing said pyrimidine compound as an active ingredient.

公开(公告)号：US08207194B2

公开(公告)日：2012-06-26

申请号：US12381290

申请日：2009-03-10

申请人： Takahiro Honda ,  Hisashi Tajima ,  Yoshimasa Sasabuchi ,  Kenji Kawashima ,  Kazuyoshi Okamoto ,  Minoru Yamamoto ,  Masakazu Ban

发明人： Takahiro Honda ,  Hisashi Tajima ,  Yoshimasa Sasabuchi ,  Kenji Kawashima ,  Kazuyoshi Okamoto ,  Minoru Yamamoto ,  Masakazu Ban

IPC分类号： A61K31/47 ,  C07D401/02 ,  C07D213/02

CPC分类号： C07D401/12 ,  C07D213/32 ,  C07D401/14

摘要： A compound having the following formula [I] or a pharmaceutically acceptable salt thereof: wherein A is benzene or an aromatic five-membered heterocycle which optionally is fused with a cycloalkane ring; B is an alkylene; R1 and R2 are hydrogen, hydroxy, alkoxy, aryloxy, alkyl, cycloalkyl, aryl, heterocycle, amino, alkylamino, arylamino or acyl, or R1 and R2 join together to form a heterocycle; X and Y are hydrogen, halogen, hydroxy, alkoxy, aryloxy, alkyl, cycloalkyl, aryl, mercapto, alkylthio, arylthio, carboxyl, an ester of carboxyl, an amide of carboxyl, cyano or nitro; p is 0, 1 or 2; and q is 0 or 1. The compound is useful for treating diseases in which angiogenesis or augmentation of vascular permeability is involved.

摘要翻译： 具有下式[I]的化合物或其药学上可接受的盐：其中A是任选与环烷烃环稠合的苯或芳族五元杂环; B是亚烷基; R 1和R 2是氢，羟基，烷氧基，芳氧基，烷基，环烷基，芳基，杂环，氨基，烷基氨基，芳基氨基或酰基，或R 1和R 2连接在一起形成杂环; X和Y是氢，卤素，羟基，烷氧基，芳氧基，烷基，环烷基，芳基，巯基，烷硫基，芳硫基，羧基，羧基的酯，羧基的酰胺，氰基或硝基; p为0,1或2; q为0或1.该化合物可用于治疗涉及血管生成或增加血管通透性的疾病。

公开(公告)号：USD658691S1

公开(公告)日：2012-05-01

申请号：US29400581

申请日：2011-08-30

申请人： Kouki Suzuki ,  Jun Yamashita ,  Masakazu Ban ,  Atsushi Ueda

设计人： Kouki Suzuki ,  Jun Yamashita ,  Masakazu Ban ,  Atsushi Ueda

公开(公告)号：US08063034B2

公开(公告)日：2011-11-22

申请号：US12449159

申请日：2008-01-29

申请人： Takahiro Honda ,  Koushi Fujisawa ,  Hiroyuki Aono ,  Masakazu Ban

发明人： Takahiro Honda ,  Koushi Fujisawa ,  Hiroyuki Aono ,  Masakazu Ban

IPC分类号： A61K31/397 ,  A61K31/4245 ,  C07D271/07 ,  C07D413/08

CPC分类号： C07D285/135 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14

摘要： The present invention relates to Compounds represented by the formula (I) or salts thereof. In the formula (I), the ring A represents a benzene ring, a thiophene ring, or a pyridine ring; Ra represents a hydrogen atom, a halogen atom, an alkyl group, or an alkoxy group; the ring B represents a pyridine ring, a pyrimidine ring, or a quinoline ring; the ring C represents a benzene ring; a pyridine ring, a quinoline ring, or an isoquinoline ring; X and Y, the same or different, represent an oxygen atom or a sulfur atom, with the proviso that the case X is a sulfur atom and Y is an oxygen atom be excluded; R1 represents a hydrogen atom, a halogen atom, an amino group, a cycloalkylamino group, an alkylcarbonylamino group, an alkyloxycarbonylamino group, an alkylaminocarbonyl group, or a non-aromatic heterocyclic group; and R2 and R2′, the same or different, represent a hydrogen atom, a halogen atom, an alkyl group, a halogeno-alkyl group, or a halogeno-alkoxy group.

摘要翻译： 本发明涉及由式（I）表示的化合物或其盐。 在式（I）中，环A表示苯环，噻吩环或吡啶环; Ra表示氢原子，卤素原子，烷基或烷氧基; 环B表示吡啶环，嘧啶环或喹啉环; 环C表示苯环; 吡啶环，喹啉环或异喹啉环; X和Y相同或不同，表示氧原子或硫原子，条件是情况X为硫原子，Y为氧原子排除; R1表示氢原子，卤素原子，氨基，环烷基氨基，烷基羰基氨基，烷氧基羰基氨基，烷基氨基羰基或非芳香族杂环基; 和R2和R2'相同或不同，表示氢原子，卤素原子，烷基，卤代烷基或卤代 - 烷氧基。

公开(公告)号：US20090286786A1

公开(公告)日：2009-11-19

申请号：US12381290

申请日：2009-03-10

申请人： Takahiro Honda ,  Hisashi Tajima ,  Yoshimasa Sasabuchi ,  Kenji Kawashima ,  Kazuyoshi Okamoto ,  Minoru Yamamoto ,  Masakazu Ban

发明人： Takahiro Honda ,  Hisashi Tajima ,  Yoshimasa Sasabuchi ,  Kenji Kawashima ,  Kazuyoshi Okamoto ,  Minoru Yamamoto ,  Masakazu Ban

IPC分类号： A61K31/5377 ,  A61K31/497 ,  A61K31/4709 ,  A61K31/444 ,  A61K31/4436 ,  A61K31/44 ,  C07D413/12 ,  C07D401/12 ,  C07D409/12 ,  C07D405/12 ,  C07D211/70 ,  A61K31/443

CPC分类号： C07D401/12 ,  C07D213/32 ,  C07D401/14

摘要： A compound having the following formula [I] or a pharmaceutically acceptable salt thereof: wherein A is benzene or an aromatic five-membered heterocycle which optionally is fused with a cycloalkane ring; B is an alkylene; R1 and R2 are hydrogen, hydroxy, alkoxy, aryloxy, alkyl, cycloalkyl, aryl, heterocycle, amino, alkylamino, arylamino or acyl, or R1 and R2 join together to form a heterocycle; X and Y are hydrogen, halogen, hydroxy, alkoxy, aryloxy, alkyl, cycloalkyl, aryl, mercapto, alkylthio, arylthio, carboxyl, an ester of carboxyl, an amide of carboxyl, cyano or nitro; p is 0, 1 or 2; and q is 0 or 1. The compound is useful for treating diseases in which angiogenesis or augmentation of vascular permeability is involved.

摘要翻译： 具有下式[I]的化合物或其药学上可接受的盐：其中A是任选与环烷烃环稠合的苯或芳族五元杂环; B是亚烷基; R 1和R 2是氢，羟基，烷氧基，芳氧基，烷基，环烷基，芳基，杂环，氨基，烷基氨基，芳基氨基或酰基，或R 1和R 2连接在一起形成杂环; X和Y是氢，卤素，羟基，烷氧基，芳氧基，烷基，环烷基，芳基，巯基，烷硫基，芳硫基，羧基，羧基的酯，羧基的酰胺，氰基或硝基; p为0,1或2; q为0或1.该化合物可用于治疗涉及血管生成或增加血管通透性的疾病。