发明申请
US20060234367A1 Methods and composition for the production of orthogonal tRNA-aminoacyltRNA synthetase pairs
有权
用于生产正交tRNA-amino酰基tRNA合成酶对的方法和组成
- 专利标题： Methods and composition for the production of orthogonal tRNA-aminoacyltRNA synthetase pairs
- 专利标题（中）： 用于生产正交tRNA-amino酰基tRNA合成酶对的方法和组成
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申请号： US11254170申请日： 2005-10-18
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公开(公告)号： US20060234367A1公开(公告)日： 2006-10-19
- 发明人: Peter Schultz , Lei Wang , John Anderson , Jason Chin , David Liu , Thomas Magliery , Eric Meggers , Ryan Mehl , Miro Pastrnak , Stephen Santoro , Zhiwen Zhang
- 申请人： Peter Schultz , Lei Wang , John Anderson , Jason Chin , David Liu , Thomas Magliery , Eric Meggers , Ryan Mehl , Miro Pastrnak , Stephen Santoro , Zhiwen Zhang
- 专利权人： The Scripps Research Institute & The Regents of the University of California
- 当前专利权人： The Scripps Research Institute & The Regents of the University of California
- 主分类号： C12N9/22
- IPC分类号： C12N9/22
摘要：
This invention provides compositions and methods for generating components of protein biosynthetic machinery including orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases. Methods for identifying orthogonal pairs are also provided. These components can be used to incorporate unnatural amino acids into proteins in vivo.
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