发明申请
- 专利标题： Methods for treating cancers and restenosis with p21
- 专利标题（中）： 用p21治疗癌症和再狭窄的方法
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申请号： US11475827申请日： 2006-06-27
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公开(公告)号： US20060239975A1公开(公告)日： 2006-10-26
- 发明人: Gary Nabel , Zhi-yong Yang , Elizabeth Nabel
- 申请人： Gary Nabel , Zhi-yong Yang , Elizabeth Nabel
- 主分类号： A61K48/00
- IPC分类号： A61K48/00 ; A61K9/127
摘要：
The p21 gene encodes a cyclin dependent kinase inhibitor which affects cell cycle progression, but the role of this gene product in altering tumor growth has not been established. The present inventors have now discovered that the growth of malignant cells in vivo is inhibited by expression of p21. Expression of p21 resulted in an accumulation of cells in G0/G1, alteration in morphology, and cell differentiation.