发明申请
US20060240036A1 I-FLICE, a novel inhibitor of tumor necrosis factor receptor-1 and CD-95 induced apoptosis
审中-公开
I-FLICE，一种新型的肿瘤坏死因子受体-1抑制剂和CD-95诱导的细胞凋亡
- 专利标题： I-FLICE, a novel inhibitor of tumor necrosis factor receptor-1 and CD-95 induced apoptosis
- 专利标题（中）： I-FLICE，一种新型的肿瘤坏死因子受体-1抑制剂和CD-95诱导的细胞凋亡
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申请号： US11445311申请日： 2006-06-02
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公开(公告)号： US20060240036A1公开(公告)日： 2006-10-26
- 发明人: Jian Ni , Craig Rosen , Vishva Dixit , Reiner Gentz , Joseph Kenny
- 申请人： Jian Ni , Craig Rosen , Vishva Dixit , Reiner Gentz , Joseph Kenny
- 申请人地址： US MD Rockville US MI Ann Arbor
- 专利权人： Human Genome Sciences, Inc.,The Regents of the University of Michigan
- 当前专利权人： Human Genome Sciences, Inc.,The Regents of the University of Michigan
- 当前专利权人地址： US MD Rockville US MI Ann Arbor
- 主分类号： A61K39/00
- IPC分类号： A61K39/00 ; C12Q1/68 ; G01N33/574 ; C07H21/04 ; C12P21/06
摘要：
The present invention relates to a novel I-FLICE-1 or I-FLICE-2 protein which is a novel inhibitor of TNFR-1 and CD-95 induced apoptosis. In particular, isolated nucleic acid molecules are provided encoding the human I-FLICE-1 or I-FLICE-2 protein. I-FLICE-1 or I-FLICE-2 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of I-FLICE-1 or I-FLICE-2 activity. Also provided are therapeutic methods for treating diseases and disorders associated with apoptosis.
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