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公开(公告)号：US20080058247A1
公开(公告)日：2008-03-06
申请号：US11832019
申请日：2007-08-01
Applicant: Jian Ni , Craig Rosen , Reiner Gentz
Inventor： Jian Ni , Craig Rosen , Reiner Gentz
CPC classification number: C07K14/70535 , A61K38/00 , C07K14/47 , C07K14/705 , C07K14/70503 , C12N9/6421 , C12N9/6475 , C12N9/6489 , C12N9/6491 , C12N2799/026
Abstract: Receptor polypeptides and polynucleotides and methods for producing such polypeptides by recombinant techniques are disclosed. Also disclosed are methods for utilizing receptor polypeptides and polynucleotides in the design of protocols for the treatment of diseases and diagnostic assays for such conditions.
Abstract translation: 公开了受体多肽和多核苷酸以及通过重组技术产生这种多肽的方法。 还公开了在设计用于治疗疾病的方案和用于这些病症的诊断测定中使用受体多肽和多核苷酸的方法。
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公开(公告)号：US20070203070A1
公开(公告)日：2007-08-30
申请号：US11744695
申请日：2007-05-04
Applicant: Craig Rosen , Steven Ruben , Yi Li , Zhizhen Zeng , Hla Kyaw , Carrie Fischer , Haodong Li , Daniel Soppet , Reiner Gentz , Ying-Fei Wei , Paul Moore , Paul Young , John Greene , Ann Ferrie , Gregg Hastings
Inventor： Craig Rosen , Steven Ruben , Yi Li , Zhizhen Zeng , Hla Kyaw , Carrie Fischer , Haodong Li , Daniel Soppet , Reiner Gentz , Ying-Fei Wei , Paul Moore , Paul Young , John Greene , Ann Ferrie , Gregg Hastings
IPC: A61K38/17 , C07H21/04 , C07K16/00 , C07K4/00 , C12N15/00 , C12N15/09 , C12N5/00 , C12N5/08 , C12Q1/00 , C12Q1/68
CPC classification number: C07K14/47 , A61K38/00 , A61K48/00 , A61K2039/53 , C07K14/4702 , C07K14/4718 , C07K2319/00 , C07K2319/02 , C12N2799/026
Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
Abstract translation: 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。
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公开(公告)号：US20060234285A1
公开(公告)日：2006-10-19
申请号：US11419656
申请日：2006-05-22
Applicant: Reiner Gentz , Guo-Liang Yu , Jian Ni , Reinhard Ebner , Ping Feng , Steven Ruben
Inventor： Reiner Gentz , Guo-Liang Yu , Jian Ni , Reinhard Ebner , Ping Feng , Steven Ruben
IPC: C12Q1/68 , G01N33/574 , A61K38/17 , C07H21/04 , C12P21/06 , C07K14/715
CPC classification number: G01N33/57488 , A61K38/00 , C07K14/70578 , C07K14/7151
Abstract: The present invention relates to novel Tumor Necrosis Factor Receptor proteins. In particular, isolated nucleic acid molecules are provided encoding the human TNFR-6α & -6β proteins. TNFR-6α & -6β polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TNFR-6α & -6β activity. Also provided are diagnostic methods for detecting immune system-related disorders and therapeutic methods for treating immune system-related disorders.
Abstract translation: 本发明涉及新型肿瘤坏死因子受体蛋白。 特别地，提供编码人TNFR-6α和-6β蛋白的分离的核酸分子。 还提供了TNFR-6α和-6β多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明还涉及鉴定TNFR-6α和-6β活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测免疫系统相关疾病的诊断方法和用于治疗免疫系统相关疾病的治疗方法。
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公开(公告)号：US20060073573A1
公开(公告)日：2006-04-06
申请号：US11244394
申请日：2005-10-06
Applicant: Jian Ni , Reiner Gentz , Guo-Liang Yu , Jeffrey Su , Patrick Dillon
Inventor： Jian Ni , Reiner Gentz , Guo-Liang Yu , Jeffrey Su , Patrick Dillon
CPC classification number: C07K14/52 , A61K38/00 , C07K14/521 , Y02A50/423
Abstract: Human chemotactic cytokine III polypeptides and DNA (RNA) encoding such chemotactic cytokines and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemotactic cytokines for the treatment of leukemia, tumors, chronic infections, auto-immune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such chemotactic cytokines and their use as a therapeutic to treat rheumatoid arthritis, auto-immune and chronic and acute inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever, cerebral ischemia, glomerulonephritis, HTLV-1 related diseases and bone marrow failure are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding chemotactic cytokine III and for detecting altered levels of the polypeptide in a host.
Abstract translation: 公开了人类趋化性细胞因子III多肽和编码这种趋化性细胞因子的DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了利用这种趋化性细胞因子治疗白血病，肿瘤，慢性感染，自身免疫疾病，纤维化病症，伤口愈合和牛皮癣的方法。 针对这种趋化性细胞因子的拮抗剂及其作为治疗类风湿性关节炎，自身免疫和慢性和急性炎症和感染性疾病，过敏反应，前列腺素不依赖性发烧，脑缺血，肾小球肾炎，HTLV-1相关疾病和骨髓衰竭的治疗用途 也被披露。 还公开了用于检测与核酸序列中的突变和多肽的改变的浓度相关的疾病的诊断测定。 还公开了用于检测编码趋化性细胞因子III的多核苷酸中的突变并用于检测宿主中多肽的改变水平的诊断测定。
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公开(公告)号：US20060045878A1
公开(公告)日：2006-03-02
申请号：US11048774
申请日：2005-02-03
Applicant: Jian Ni , Reiner Gentz , Steven Ruben , Y. Shi
Inventor： Jian Ni , Reiner Gentz , Steven Ruben , Y. Shi
IPC: C07H21/04 , A61K39/395 , C07K16/44 , C12N5/06
CPC classification number: C07K14/81 , A61K38/00 , A61K48/00 , C07K14/8132 , C07K2319/00 , Y02A50/463
Abstract: The present invention relates to a novel member of the plasminogen activator inhibitor protein family. In particular, isolated nucleic acid molecules are provided encoding the pancreas-derived plasminogen activator inhibitor protein. Pancreas-derived plasminogen activator inhibitor polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to methods for treating physiologic and pathologic disease conditions and diagnostic methods for detecting pathologic disorders.
Abstract translation: 本发明涉及纤溶酶原激活物抑制剂蛋白家族的新成员。 特别地，提供编码胰腺衍生的纤溶酶原激活物抑制蛋白的分离的核酸分子。 还提供了胰腺来源的纤溶酶原激活物抑制剂多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明还涉及用于治疗生理和病理疾病状况的方法以及用于检测病理学疾病的诊断方法。
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Patent Agency Ranking
公开(公告)号：US20050208621A1
公开(公告)日：2005-09-22
申请号：US10951993
申请日：2004-09-29
Applicant: Craig Rosen , Steven Ruben , Yi Li , ZhiZhen Zeng , Hla Kyaw , Carrie Fishcher , Haodong Li , Daniel Soppet , Reiner Gentz , Ying-Fei Wei , Paul Moore , Paul Young , John Greene , Ann Ferrie , Gregg Hastings
Inventor： Craig Rosen , Steven Ruben , Yi Li , ZhiZhen Zeng , Hla Kyaw , Carrie Fishcher , Haodong Li , Daniel Soppet , Reiner Gentz , Ying-Fei Wei , Paul Moore , Paul Young , John Greene , Ann Ferrie , Gregg Hastings
CPC classification number: C07K14/47 , A61K38/00 , A61K48/00 , A61K2039/53 , C07K14/4702 , C07K14/4718 , C07K2319/00 , C07K2319/02 , C12N2799/026
Abstract: The present invention relates to novel human secreted proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells, antibodies, and recombinant methods for producing human secreted proteins. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating diseases, disorders, and/or conditions related to these novel human secreted proteins.
Abstract translation: 本发明涉及含有编码这些蛋白质的基因的编码区的新的人分泌蛋白和分离的核酸。 还提供了用于产生人分泌蛋白质的载体，宿主细胞，抗体和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的疾病，病症和/或病症的诊断和治疗方法。
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公开(公告)号：US20050119457A1
公开(公告)日：2005-06-02
申请号：US10314942
申请日：2002-12-10
Applicant: Jian Ni , Craig Rosen , Reiner Gentz , Jeffrey Su , Geoffrey Krissansen , Ping Feng
Inventor： Jian Ni , Craig Rosen , Reiner Gentz , Jeffrey Su , Geoffrey Krissansen , Ping Feng
IPC: C12N15/09 , A61K38/00 , A61K45/00 , A61K48/00 , A61P35/00 , C07K14/47 , C07K14/705 , C07K14/735 , C07K16/18 , C07K16/28 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/64 , C12N15/12 , C12Q1/68 , G01N33/15 , G01N33/50 , C07H21/04
CPC classification number: C07K14/70535 , A61K38/00 , C07K14/47 , C07K14/705 , C07K14/70503 , C12N9/6421 , C12N9/6475 , C12N9/6489 , C12N9/6491 , C12N2799/026
Abstract: The present invention relates to novel human proteins and isolated nucleic acids containing the coding regions of the genes encoding such proteins. Also provided are vectors, host cells and recombinant methods for producing the proteins of the invention. The invention further relates to diagnostic and therapeutic methods useful for diagnosing and treating disorders related to these novel human secreted proteins.
Abstract translation: 本发明涉及包含编码这种蛋白质的基因的编码区的新型人类蛋白质和分离的核酸。 还提供了用于产生本发明的蛋白质的载体，宿主细胞和重组方法。 本发明还涉及用于诊断和治疗与这些新型人分泌蛋白相关的病症的诊断和治疗方法。
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公开(公告)号：US20050037966A1
公开(公告)日：2005-02-17
申请号：US10901210
申请日：2004-07-29
Applicant: Steven Ruben , Pablo Jimenez , Roxanne Duan , Mark Rampy , Donna Mendrick , Jun Zhang , Jian Ni , Paul Moore , Timothy Coleman , Joachim Gruber , Patrick Dillon , Reiner Gentz
Inventor： Steven Ruben , Pablo Jimenez , Roxanne Duan , Mark Rampy , Donna Mendrick , Jun Zhang , Jian Ni , Paul Moore , Timothy Coleman , Joachim Gruber , Patrick Dillon , Reiner Gentz
CPC classification number: C07K14/50 , A01K2217/05 , A01K2217/075 , A61K38/00 , A61K48/00
Abstract: This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides. More particularly, the polypeptide of the present invention is a Keratinocyte Growth Factor, sometimes hereinafter referred to as “KGF-2” also formerly known as Fibroblast Growth Factor 12 (FGF-12). This invention further relates to the therapeutic use of KGF-2 to promote or accelerate wound healing. This invention also relates to novel mutant forms of KGF-2 that show enhanced activity, increased stability, higher yield or better solubility.
Abstract translation: 本发明涉及新鉴定的多核苷酸，由这种多核苷酸编码的多肽，这种多核苷酸和多肽的用途，以及这种多核苷酸和多肽的产生。 更具体地，本发明的多肽是角质形成细胞生长因子，有时在下文中称为“KGF-2”，以前称为成纤维细胞生长因子12（FGF-12）。 本发明还涉及KGF-2促进或加速伤口愈合的治疗用途。 本发明还涉及显示增强的活性，增加的稳定性，更高的产量或更好的溶解度的KGF-2的新型突变形式。
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公开(公告)号：US20050009141A1
公开(公告)日：2005-01-13
申请号：US10915596
申请日：2004-08-11
Applicant: Jian Ni , Ping Feng , Patrick Dillon , Reiner Gentz , Joseph Merregaert , Patrick Smits
Inventor： Jian Ni , Ping Feng , Patrick Dillon , Reiner Gentz , Joseph Merregaert , Patrick Smits
IPC: G01N33/50 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P43/00 , C07K14/47 , C07K14/485 , C07K16/22 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12Q1/02 , C12Q1/68 , C12R1/91 , G01N33/15 , G01N33/53 , G01N33/566 , G01N33/577 , C07K14/705 , C07H21/04 , C07K16/28
CPC classification number: C07K14/47 , A61K38/00 , A61K48/00 , C12N2799/026
Abstract: A human epidermal differentiation factor polypeptide and DNA (RNA) encoding such polypeptide and procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for treating and/or preventing skin diseases. Diagnostic assays for detecting mutations in a nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention are also disclosed.
Abstract translation: 公开了通过重组技术产生这种多肽的人表皮分化因子多肽和编码这种多肽的DNA（RNA）和方法。 还公开了利用这种多肽治疗和/或预防皮肤疾病的方法。 还公开了用于检测编码本发明多肽的核酸序列中的突变并用于检测本发明多肽的改变水平的诊断测定。
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公开(公告)号：US6130061A
公开(公告)日：2000-10-10
申请号：US746397
申请日：1996-11-08
Applicant: Jian Ni , Guo-Liang Yu , Reiner Gentz , Jeannine D. Gocayne
Inventor： Jian Ni , Guo-Liang Yu , Reiner Gentz , Jeannine D. Gocayne
CPC classification number: C07K14/705 , A61K38/00
Abstract: A human stem cell antigen 2 polypeptide and DNA (RNA) encoding such polypeptide and a procedure for producing such polypeptide by recombinant techniques is disclosed. Also disclosed are methods for utilizing such polypeptide for stimulating thymocyte maturation and differentiation, protecting neuronal cells, preventing rejection during organ transplantation, treating PNH, Alzheimer's Disease and inflammation is disclosed. Diagnostic assays for identifying mutations in nucleic acid sequence encoding a polypeptide of the present invention and for detecting altered levels of the polypeptide of the present invention for detecting diseases, for example, cancer, are also disclosed.
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