发明申请
US20060241177A1 Novel compounds, pharmaceutical compositions containing same, and methods of use for same
审中-公开
新型化合物,含有它们的药物组合物及其用途方法
- 专利标题: Novel compounds, pharmaceutical compositions containing same, and methods of use for same
- 专利标题(中): 新型化合物,含有它们的药物组合物及其用途方法
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申请号: US10519804申请日: 2003-07-01
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公开(公告)号: US20060241177A1公开(公告)日: 2006-10-26
- 发明人: Francis Kuhadja , Susan Medghalchi , Jagan Thupari , Craig Townsend , Jill McFadden
- 申请人: Francis Kuhadja , Susan Medghalchi , Jagan Thupari , Craig Townsend , Jill McFadden
- 国际申请: PCT/US03/20960 WO 20030701
- 主分类号: A61K31/365
- IPC分类号: A61K31/365 ; C07D305/12
摘要:
Pharmaceutical composition comprising a pharmaceutical diluent and a compound of formula IX: R29═H, or C1-C20 alkyl, cycloalkyl, alkenyl, aryl, arylalkyl, or alkylaryl, ═CHR31, —C(O)OR31, —C(O)R31, —CH2C(O)OR31, CH2C(O)NHR31, where R31 is H or C1-C10 alkyl, cycloalkyl, or alkenyl; R30═C1-C20 alkyl, cycloalkyl, alkenyl, aryl, arylalkyl, or alkylaryl; X5═—OR32, or NHR32, Where R32 is H, C1-C20 alkyl, cycloalkyl, alkenyl, aryl, arylalkyl, or alkylaryl, the R32 group optionally containing a carbonyl group, a carboxyl group, a carboxyamide group, an alcohol group, or an ether group, the R32 group further optionally containing one or more halogen atoms; with the proviso that when R29 is ═CH2, then X5 is not OH. Also disclosed are compounds within the scope of the formula IX, as well as uses of the pharmaceutical compositions for weight loss, anti-microbial and anti-cancer applications, inhibition of fatty acid synthase and neuropeptide-Y, and the stimulation of the activity of carnitine palmitoyl transferase-1.