公开(公告)号：US20060241177A1

公开(公告)日：2006-10-26

申请号：US10519804

申请日：2003-07-01

申请人： Francis Kuhadja ,  Susan Medghalchi ,  Jagan Thupari ,  Craig Townsend ,  Jill McFadden

发明人： Francis Kuhadja ,  Susan Medghalchi ,  Jagan Thupari ,  Craig Townsend ,  Jill McFadden

IPC分类号： A61K31/365 ,  C07D305/12

CPC分类号： C07D307/33 ,  C07D307/58 ,  C07D307/68

摘要： Pharmaceutical composition comprising a pharmaceutical diluent and a compound of formula IX: R29═H, or C1-C20 alkyl, cycloalkyl, alkenyl, aryl, arylalkyl, or alkylaryl, ═CHR31, —C(O)OR31, —C(O)R31, —CH2C(O)OR31, CH2C(O)NHR31, where R31 is H or C1-C10 alkyl, cycloalkyl, or alkenyl; R30═C1-C20 alkyl, cycloalkyl, alkenyl, aryl, arylalkyl, or alkylaryl; X5═—OR32, or NHR32, Where R32 is H, C1-C20 alkyl, cycloalkyl, alkenyl, aryl, arylalkyl, or alkylaryl, the R32 group optionally containing a carbonyl group, a carboxyl group, a carboxyamide group, an alcohol group, or an ether group, the R32 group further optionally containing one or more halogen atoms; with the proviso that when R29 is ═CH2, then X5 is not OH. Also disclosed are compounds within the scope of the formula IX, as well as uses of the pharmaceutical compositions for weight loss, anti-microbial and anti-cancer applications, inhibition of fatty acid synthase and neuropeptide-Y, and the stimulation of the activity of carnitine palmitoyl transferase-1.

摘要翻译： 包含药物稀释剂和式IX化合物的药物组合物：R 29 -H或C 1 -C 20烷基，环烷基，烯基 ，芳基，芳烷基或烷基芳基，-CHR 31，-C（O）OR 31，-C（O）R 31， - CH 2 C（O）OR 31，CH 2 C（O）NHR 31，其中R SUP > 31是H或C 1 -C 10烷基，环烷基或链烯基; 烷基，环烷基，烯基，芳基，芳基烷基或烷基芳基;其中R 1，R 2，R 2，R 3， 其中R 32为H，C 1〜S 12，或其中R 32为H，C 1〜 烷基，环烷基，烯基，芳基，芳烷基或烷基芳基，任选含有羰基，羧基，羧酰胺的R 32基团 基团，醇基团或醚基团，R 32基团还任选地含有一个或多个卤素原子; 条件是当R 29为-CH 2时，则X 5不是OH。 还公开了式IX范围内的化合物，以及药物组合物用于体重减轻，抗微生物和抗癌应用，抑制脂肪酸合酶和神经肽Y的用途以及刺激活性 肉碱棕榈酰转移酶-1。