- 专利标题: Delivery of analgesics through an inhalation route
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申请号: US11479892申请日: 2006-06-30
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公开(公告)号: US20060251587A1公开(公告)日: 2006-11-09
- 发明人: Joshua Rabinowitz , Alejandro Zaffaroni
- 申请人: Joshua Rabinowitz , Alejandro Zaffaroni
- 申请人地址: US CA Palo Alto
- 专利权人: Alexza Pharmaceuticals, Inc.
- 当前专利权人: Alexza Pharmaceuticals, Inc.
- 当前专利权人地址: US CA Palo Alto
- 主分类号: A61K9/14
- IPC分类号: A61K9/14 ; A61L9/04
摘要:
The present invention relates to the delivery of analgesics through an inhalation route. Specifically, it relates to aerosols containing acetaminophen, orphenadrine or tramadol that are used in inhalation therapy. In a method aspect of the present invention, an analgesic is administered to a patient through an inhalation route. The method comprises: a) heating a thin layer of acetaminophen, orphenadrine or tramadol, on a solid support to form a vapor; and, b) passing air through the heated vapor to produce aerosol particles having less than 5% acetaminophen, orphenadrine or tramadol degradation products. In a kit aspect of the present invention, a kit for delivering acetaminophen, orphenadrine or tramadol through an inhalation is provided which comprises: a) a thin coating of an acetaminophen, orphenadrine or tramadol composition and b) a device for dispensing said thin coating as a condensation aerosol.
公开/授权文献
- US07449174B2 Delivery of analgesics through an inhalation route 公开/授权日:2008-11-11
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