发明申请
- 专利标题： Fki-1366 substances and process for producing the same
- 专利标题（中）： Fki-1366物质及其生产方法
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申请号： US10548452申请日： 2003-08-29
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公开(公告)号： US20060252930A1公开(公告)日： 2006-11-09
- 发明人: Satoshi Omura , Hiroshi Tomoda , Rokura Masuma , Masayoshi Arai
- 申请人： Satoshi Omura , Hiroshi Tomoda , Rokura Masuma , Masayoshi Arai
- 国际申请： PCT/JP03/11053 WO 20030829
- 主分类号： C07D267/22
- IPC分类号： C07D267/22 ; C07K7/60
摘要：
A microorganism belonging to Beauveria sp. and having ability to produce FKI-1366 substance A and/or FKI-1366 substance B and/or FKI-1366 substance C (Beauveria sp. FKI-1366 FERM BP-08459) is cultured in a medium, accumulating FKI-1366 substance A and/or FKI-1366 substance B and/or FKI-1366 substance C in the culture liquid and isolating FKI-1366 substance A and/or FKI-1366 substance B and/or FKI-1366 substance C from the cultured mass. Since the thus obtained FKI-1366 substance A and/or FKI-1366 substance B and/or FKI-1366 substance C or composition thereof have activity to enhance azole antifungal agent, the substance has an action against various fungal infections such as deep-seated mycosis and other fungal infections in the low concentration within short term. Consequently, the substance is useful for reducing frequency of appearance of resistant microorganisms and overcoming resistance, and is expected as a medicament.
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