公开(公告)号：US20060252930A1

公开(公告)日：2006-11-09

申请号：US10548452

申请日：2003-08-29

申请人： Satoshi Omura ,  Hiroshi Tomoda ,  Rokura Masuma ,  Masayoshi Arai

发明人： Satoshi Omura ,  Hiroshi Tomoda ,  Rokura Masuma ,  Masayoshi Arai

IPC分类号： C07D267/22 ,  C07K7/60

CPC分类号： C12P17/14 ,  A61K31/395 ,  C07D273/00 ,  C12R1/645

摘要： A microorganism belonging to Beauveria sp. and having ability to produce FKI-1366 substance A and/or FKI-1366 substance B and/or FKI-1366 substance C (Beauveria sp. FKI-1366 FERM BP-08459) is cultured in a medium, accumulating FKI-1366 substance A and/or FKI-1366 substance B and/or FKI-1366 substance C in the culture liquid and isolating FKI-1366 substance A and/or FKI-1366 substance B and/or FKI-1366 substance C from the cultured mass. Since the thus obtained FKI-1366 substance A and/or FKI-1366 substance B and/or FKI-1366 substance C or composition thereof have activity to enhance azole antifungal agent, the substance has an action against various fungal infections such as deep-seated mycosis and other fungal infections in the low concentration within short term. Consequently, the substance is useful for reducing frequency of appearance of resistant microorganisms and overcoming resistance, and is expected as a medicament.

摘要翻译： 属于白僵菌的微生物 并且在培养基中培养产生FKI-1366物质A和/或FKI-1366物质B和/或FKI-1366物质C（白僵菌FKI-1366FERM BP-08459）的能力，将FKI-1366物质A 和/或FKI-1366物质B和/或FKI-1366物质C，并从培养物质中分离FKI-1366物质A和/或FKI-1366物质B和/或FKI-1366物质C。 由于如此获得的FKI-1366物质A和/或FKI-1366物质B和/或FKI-1366物质C或其组合物具有增强唑类抗真菌剂的活性，所以该物质具有针对各种真菌感染的作用，例如深层 短期内低浓度的真菌病和其他真菌感染。 因此，该物质可用于降低抗性微生物的出现频率并克服抗性，并且预期作为药物。

公开(公告)号：US20050176655A1

公开(公告)日：2005-08-11

申请号：US10472044

申请日：2002-10-29

申请人： Satoshi Omura ,  Hiroshi Tomoda ,  Toshiaki Sunazuka ,  Masayoshi Arai ,  Tohru Nagamitsu

发明人： Satoshi Omura ,  Hiroshi Tomoda ,  Toshiaki Sunazuka ,  Masayoshi Arai ,  Tohru Nagamitsu

IPC分类号： A01N43/04 ,  A61K31/7048 ,  A61P31/10 ,  C07H17/08

CPC分类号： C07H17/08 ,  A61K31/7048

摘要： Macrolide derivatives having enhancing effect for activities of azole antifungal agents, acting at low concentration and within a short time against fungal infection and reducing the frequency of appearance of resistant microorganisms. One such substance is a compound represented by the formula [I]: wherein R1 is Ac, R2 and R3 are Ac, and R4 is Me; when R1 is H, R2 and R3 are Ac, and R4 is Me; when R1 is H, R2 and R3 are Ac, and R4 is H, when R1 Bzl, R2 and R3 are Bzl, and R4 is Me; when R1 is Ac, R2 and R3 are Pr, and R4 is Me; when R1 is Ac, R2 and R3 are Hex, and R4 is Me; when R1 is Ac, R2 and R3 are Bzl, and R4 is Me; when R1 is H, R2 and R3 are Pr, and R4 is Me; when R1 is H, R2 and R3 are Hex, and R4 is Me; when R1 is H, R2 and R3 are Bzl, and R4 is Me; when R1 is H, R2 is H, R3 is Bzl, and R4 is Me; when R1 is H, R2 and R3 are Hex, and R4 is H, or when R1 is H, R2 and R3 are Hex, and R4 is Et.

摘要翻译： 大环内酯衍生物对唑类抗真菌剂的活性具有增强的作用，在低浓度和短时间内对真菌感染起作用，并降低抗性微生物出现的频率。 一种这样的物质是由式[I]表示的化合物：其中R1是Ac，R2和R3是Ac，R4是Me; 当R1为H时，R2和R3为Ac，R4为Me; 当R1为H时，R2和R3为Ac，R4为H时，当R1Bz1，R2和R3为Bz1，R4为Me时; 当R1为Ac时，R2和R3为Pr，R4为Me; 当R1为Ac时，R2和R3为Hex，R4为Me; 当R1为Ac时，R2和R3为Bz1，R4为Me; 当R1为H时，R2和R3为Pr，R4为Me; 当R1为H时，R2和R3为Hex，R4为Me; 当R1为H时，R2和R3为Bz1，R4为Me; 当R1为H时，R2为H，R3为Bz1，R4为Me; 当R1为H时，R2和R3为Hex，R4为H，或当R1为H时，R2和R3为Hex，R4为Et。

公开(公告)号：US07521428B2

公开(公告)日：2009-04-21

申请号：US10472044

申请日：2002-10-29

申请人： Satoshi Omura ,  Hiroshi Tomoda ,  Toshiaki Sunazuka ,  Masayoshi Arai ,  Tohru Nagamitsu

发明人： Satoshi Omura ,  Hiroshi Tomoda ,  Toshiaki Sunazuka ,  Masayoshi Arai ,  Tohru Nagamitsu

IPC分类号： A61K31/70 ,  C07H17/08

CPC分类号： C07H17/08 ,  A61K31/7048

摘要： Macrolide derivatives having enhancing effect for activities of azole antifungal agents, acting at low concentration and within a short time against fungal infection and reducing the frequency of appearance of resistant microorganisms. One such substance is a compound represented by the formula [I]: wherein R1 is Ac, R2 and R3 are Ac, and R4 is Me; when R1 is H, R2 and R3 are Ac, and R4 is Me; when R1 is H, R2 and R3 are Ac, and R4 is H, when R1 Bzl, R2 and R3 are Bzl, and R4 is Me; when R1 is Ac, R2 and R3 are Pr, and R4 is Me; when R1 is Ac, R2 and R3 are Hex, and R4 is Me; when R1 is Ac, R2 and R3 are Bzl, and R4 is Me; when R1 is H, R2 and R3 are Pr, and R4 is Me; when R1 is H, R2 and R3 are Hex, and R4 is Me; when R1 is H, R2 and R3 are Bzl, and R4 is Me; when R1 is H, R2 is H, R3 is Bzl, and R4 is Me; when R1 is H, R2 and R3 are Hex, and R4 is H, or when R1 is H, R2 and R3 are Hex, and R4 is Et.

摘要翻译： 大环内酯衍生物对唑类抗真菌剂的活性具有增强的作用，在低浓度和短时间内对真菌感染起作用，并降低抗性微生物出现的频率。 一种这样的物质是由式[I]表示的化合物：其中R1是Ac，R2和R3是Ac，R4是Me; 当R1为H时，R2和R3为Ac，R4为Me; 当R1为H时，R2和R3为Ac，R4为H时，当R1Bz1，R2和R3为Bz1，R4为Me时; 当R1为Ac时，R2和R3为Pr，R4为Me; 当R1为Ac时，R2和R3为Hex，R4为Me; 当R1为Ac时，R2和R3为Bz1，R4为Me; 当R1为H时，R2和R3为Pr，R4为Me; 当R1为H时，R2和R3为Hex，R4为Me; 当R1为H时，R2和R3为Bz1，R4为Me; 当R1为H时，R2为H，R3为Bz1，R4为Me; 当R1为H时，R2和R3为Hex，R4为H，或当R1为H时，R2和R3为Hex，R4为Et。

公开(公告)号：US06790968B1

公开(公告)日：2004-09-14

申请号：US10169551

申请日：2002-10-24

申请人： Satoshi Omura ,  Hiroshi Tomoda ,  Rokuro Masuma ,  Masayoshi Arai

发明人： Satoshi Omura ,  Hiroshi Tomoda ,  Rokuro Masuma ,  Masayoshi Arai

IPC分类号： C07D30936

CPC分类号： C07D309/38 ,  C12P17/06

摘要： A microorganism having ability to produce FKI-0076 substance represented by the following formula [I] is cultured in a medium allowing for the accumulation of FKI-0076 substance in the culture liquid. The FKI-0076 substance from can then be isolated the cultured mass. Since the substance has the ability to enhance azole antifungal agents, it provides an action against various fungal infections such as deep-seated mycosis and other fungal infections in low concentration and within a short term. Consequently, the FKI-0076 is useful for reducing the frequency of appearance of resistant microorganisms. Further, usefulness for overcoming resistance is expected.

摘要翻译： 将能够产生下式[I]表示的FKI-0076物质的微生物培养在允许培养液中积累FKI-0076物质的培养基中。 然后可以将FKI-0076物质分离出培养的物质。 由于该物质具有增强唑类抗真菌剂的能力，因此可提供针对各种真菌感染的作用，例如低浓度和短期内的深层真菌病和其他真菌感染。 因此，FKI-0076可用于降低抗性微生物的出现频率。 此外，期望克服阻力的有用性。

公开(公告)号：US20070273852A1

公开(公告)日：2007-11-29

申请号：US11662591

申请日：2006-06-30

申请人： Masayoshi Arai

发明人： Masayoshi Arai

IPC分类号： G03B27/42 ,  G03B27/52

CPC分类号： G03F7/70458 ,  G03F7/7005 ,  G03F7/70525 ,  G03F7/70558 ,  G03F7/70575 ,  G03F7/70625 ,  H01S3/10069 ,  H01S3/1055 ,  H01S3/1394 ,  H01S3/225 ,  H01S2301/08

摘要： An exposure apparatus is equipped with a laser unit that emits a laser beam, a memory that stores a first information which shows a first relation indicating a relation between a linewidth error of a pattern formed on a wafer and a spectral characteristic of the laser beam emitted from the laser unit, and a main controller that controls the spectral width of the laser beam via a laser controller, based on the first information and on information related to a reticle that is to be used. Main controller performs spectral width control of the laser beam so as to suppress linewidth error, based on the first information and on the information related to the reticle that is to be used.

摘要翻译： 曝光装置配备有发射激光束的激光单元，存储第一信息的存储器，该第一信息表示表示晶片上形成的图案的线宽误差与发射的激光束的光谱特性之间的关系的第一关系 以及通过激光控制器控制激光束的光谱宽度的主控制器，基于第一信息和与要使用的掩模版有关的信息。 主控制器根据第一信息和与要使用的掩模版有关的信息，进行激光束的光谱宽度控制，以抑制线宽误差。

公开(公告)号：US20100206487A1

公开(公告)日：2010-08-19

申请号：US12670321

申请日：2008-07-23

申请人： Masayoshi Arai ,  Shigetomi Morita

发明人： Masayoshi Arai ,  Shigetomi Morita

IPC分类号： B23K1/06 ,  B32B37/00

CPC分类号： B29C66/8227 ,  B23K20/106 ,  B29C65/08 ,  B29C66/1122 ,  B29C66/43 ,  B29C66/80 ,  B29C66/81433 ,  B29C66/8167 ,  B29C66/8322 ,  B29C66/9513

摘要： The present invention solves the problem that a connecting portion between a horn and a vibration transmission rod has a tendency to get damaged and the problem associated with the structure in which a chip is attached to an end of the vibration transmission rod, which occur with the known ultrasonic vibration welder. A vibration transmission rod has an end surface serving as a vibration-and-pressure application surface, and a polygonal cross section. The vibration transmission rod is disposed at an end of a horn in such a manner that they vibrate together. The vibration transmission rod and a mass are formed separately. The mass applies pressure to a projection formed at a nodal point of the vibration transmission rod.

摘要翻译： 本发明解决了喇叭和振动传动杆之间的连接部分具有被损坏的倾向的问题，以及与传动杆端部附接有芯片的结构有关的问题， 已知超声波振动焊机。 振动传递杆具有用作振动和压力施加表面的端面和多边形横截面。 振动传递杆以它们一起振动的方式设置在喇叭的一端。 振动传递杆和质量分别形成。 质量对形成在振动传递杆的节点处的突起施加压力。

公开(公告)号：US09371301B2

公开(公告)日：2016-06-21

申请号：US13696425

申请日：2011-05-06

申请人： Motomasa Kobayashi ,  Naoyuki Kotoku ,  Masayoshi Arai ,  Takashi Kawachi

发明人： Motomasa Kobayashi ,  Naoyuki Kotoku ,  Masayoshi Arai ,  Takashi Kawachi

IPC分类号： C07D307/36 ,  C07D333/06 ,  A61K31/341 ,  A61K31/381 ,  A61K45/06 ,  C07D333/08

CPC分类号： C07D307/36 ,  A61K31/341 ,  A61K31/381 ,  A61K45/06 ,  C07D333/08 ,  A61K2300/00

摘要： A compound represented by the general formula (C): (wherein R101 represents a substituted or unsubstituted aromatic heterocyclic group, R102, R103, R104 and R105 may be the same or different, and each represents a hydrogen atom, a halogen atom, an alkyl group having 1 to 3 carbon atoms, or a haloalkyl group having 1 to 3 carbon atoms, and R106 represents a hydrogen atom, or a saturated or unsaturated hydrocarbon group which is a straight or branched chain having 1 to 12 carbon atoms, but excluded is the case where R101 is a 3-furyl group, R102, R103, R104 and R105 are all methyl groups, and R106 is a methyl group, a 4-methyl-3-pentenyl group or a 4,8-dimethyl-3,7-nonadienyl group); or a pharmaceutically acceptable salt thereof has selective inhibitory activity on hypoxic cell growth in a broad range of the concentration and therefore is useful as an active ingredient of a medicament for cancer prevention or treatment.

摘要翻译： 由通式（C）表示的化合物：（其中R 101表示取代或未取代的芳族杂环基，R 102，R 103，R 104和R 105可以相同或不同，表示氢原子，卤素原子，烷基 具有1至3个碳原子的烷基或具有1至3个碳原子的卤代烷基，R 10 6表示氢原子，或具有1至12个碳原子的直链或支链的饱和或不饱和烃基，但不包括 R 101为3-呋喃基的情况，R102，R103，R104，R105均为甲基，R106为甲基，4-甲基-3-戊烯基或4,8-二甲基-3,7 - 壬二烯基）; 或其药学上可接受的盐在宽范围的浓度下对缺氧细胞生长具有选择性抑制活性，因此可用作用于癌症预防或治疗的药物的活性成分。

公开(公告)号：US07931706B2

公开(公告)日：2011-04-26

申请号：US11902247

申请日：2007-09-20

申请人： Masayoshi Arai ,  Tatsuro Watanabe ,  Akira Saito ,  Sachio Nakazaki ,  Toshihisa Maruta ,  Hiroyuki Takano

发明人： Masayoshi Arai ,  Tatsuro Watanabe ,  Akira Saito ,  Sachio Nakazaki ,  Toshihisa Maruta ,  Hiroyuki Takano

IPC分类号： C10L5/00

CPC分类号： C10L5/46 ,  F23G2206/201 ,  F23G2900/50208 ,  Y02E20/363 ,  Y02E50/10 ,  Y02E50/30

摘要： A cement kiln from which its brick lining has been removed, or a rotary dryer for cement production is used as a fermentation treatment apparatus 202 for converting waste matter into compost. The waste matter to be subjected to the fermentation treatment includes city waste contained in garbage bags, and its fermentation treatment is carried out by introducing the waste matter directly into the aforesaid cement kiln or the aforesaid rotary dryer for cement production without tearing the aforesaid garbage bags.

摘要翻译： 作为用于将废物转化为堆肥的发酵处理装置202，使用从其排除砖衬的水泥窑或用于水泥生产的旋转干燥器。 要进行发酵处理的废物包括垃圾袋中所含的城市废物，其发酵处理是通过将废物直接引入上述水泥窑或上述用于水泥生产的旋转干燥器中进行的，而不会撕裂上述垃圾袋 。

公开(公告)号：US07285141B2

公开(公告)日：2007-10-23

申请号：US10101541

申请日：2002-03-20

申请人： Masayoshi Arai ,  Tatsuro Watanabe ,  Akira Saito ,  Sachio Nakazaki ,  Toshihisa Maruta ,  Hiroyuki Takano

发明人： Masayoshi Arai ,  Tatsuro Watanabe ,  Akira Saito ,  Sachio Nakazaki ,  Toshihisa Maruta ,  Hiroyuki Takano

IPC分类号： C10L5/00 ,  C10L5/40

CPC分类号： C10L5/46 ,  F23G2206/201 ,  F23G2900/50208 ,  Y02E20/363 ,  Y02E50/10 ,  Y02E50/30

摘要： A cement kiln from which its brick lining has been removed, or a rotary dryer for cement production is used as a fermentation treatment apparatus 202 for converting waste matter into compost. The waste matter to be subjected to the fermentation treatment includes city waste contained in garbage bags, and its fermentation treatment is carried out by introducing the waste matter directly into the aforesaid cement kiln or the aforesaid rotary dryer for cement production without tearing the aforesaid garbage bags.

摘要翻译： 作为用于将废物转化为堆肥的发酵处理装置202，使用从其排除砖衬的水泥窑或用于水泥生产的旋转干燥器。 要进行发酵处理的废物包括垃圾袋中所含的城市废物，其发酵处理是通过将废物直接引入上述水泥窑或上述用于水泥生产的旋转干燥器中进行的，而不会撕裂上述垃圾袋 。

公开(公告)号：US08791263B2

公开(公告)日：2014-07-29

申请号：US13823265

申请日：2011-09-16

申请人： Motomasa Kobayashi ,  Naoyuki Kotoku ,  Masayoshi Arai ,  Satoru Tamura

发明人： Motomasa Kobayashi ,  Naoyuki Kotoku ,  Masayoshi Arai ,  Satoru Tamura

IPC分类号： C07D405/04 ,  C07D217/02 ,  A61K45/00 ,  A61K31/4725 ,  A61P43/00 ,  A61P35/00 ,  C07D407/10 ,  C07F7/18 ,  A61K45/06

CPC分类号： C07D407/10 ,  A61K31/4725 ,  A61K45/06 ,  C07D405/04 ,  C07F7/1804

摘要： A compound represented by the general formula (M): (wherein R1 represents a substituted or unsubstituted aromatic heterocyclic group, R2 represents a hydrogen atom, a substituted or unsubstituted alkyl group having 1 to 3 carbon atoms, OR3, N(R3)2, C(═O)OR3 or C(═O)N(R3)2, R3 represents a hydrogen atom, an alkyl group having 1 to 4 carbon atoms, or an acyl group having 1 to 4 carbon atoms, R4 represents a hydrogen atom, an oxygen atom or OR5, and R5 represents a hydrogen atom, an alkyl group having 1 to 3 carbon atoms, or an acyl group having 1 to 3 carbon atoms); or a pharmaceutically acceptable salt thereof is a cortistatin A analog which is useful as an active ingredient of medicaments for cancer prevention or treatment in that the analog can be mass-produced by chemical synthesis due to its simple chemical structure and retains the same biological activities as those of cortistatin A.

摘要翻译： 由通式（M）表示的化合物：其中，R1表示取代或未取代的芳香族杂环基，R2表示氢原子，取代或未取代的碳原子数1〜3的烷基，OR3，N（R3）2， C（= O）OR 3或C（= O）N（R3）2，R3表示氢原子，碳原子数1〜4的烷基或碳原子数1〜4的酰基，R4表示氢原子 ，氧原子或OR 5，R5表示氢原子，碳原子数1〜3的烷基或碳原子数1〜3的酰基）。 或其药学上可接受的盐是可用作癌症预防或治疗药物的活性成分的皮质激素A类似物，因为类似物可以通过化学合成由于其简单的化学结构而大规模生产，并保持与 皮质激素A.