- 专利标题: Method of estimating drug metabolic activity by analyzing mutations in glucuronosyl transferase gene
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申请号: US10524278申请日: 2003-02-13
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公开(公告)号: US20060257960A1公开(公告)日: 2006-11-16
- 发明人: Hiroshi Sato , Yoshihide Fujiyama , Kazuo Yamamoto
- 申请人: Hiroshi Sato , Yoshihide Fujiyama , Kazuo Yamamoto
- 优先权: JP2002-235029 20020812
- 国际申请: PCT/JP03/01475 WO 20030213
- 主分类号: C12Q1/48
- IPC分类号: C12Q1/48
摘要:
An object of this invention is to provide a method for assaying, predicting or assessing drug metabolism by effectively detecting (a) mutation(s) in a gene coding for UGT. A gene coding for UGT comprises 5 exons, and since the regions of exons 2 through 5 are common to each isoform of UGT1, by assaying a mutation in the common regions, particularly a mutation in exon 5 region, and further adding the detection of (a) mutation(s) in a plurality of exon regions, mutations of UGT1 gene can effectively assayed. A nucleic acid chip using nucleic acid probes is used as a way of detecting (a) mutation(s).
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