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发明申请
US20060258609A1 Method for inhibition of lipogenesis by regulating PRP19 expression 审中-公开
通过调节PRP19表达抑制脂肪生成的方法

Method for inhibition of lipogenesis by regulating PRP19 expression
摘要：
The downregulation of PRP 19 (precursor RNA processing 19) protein expression results in effectively reducing the expression of SCD1 (stearyl CoA desaturase-1), the key lipogenic enzyme, and its down-stream triacylglycerol synthesis enzymes, DGAT-1 (diacyglycerol acyltransferase-1) and GPAT (glycerol-phosphate acyltransferase), as well as the intracellular content of neutral lipids, the major target for treating obesity.
摘要（中）：

PRP19（前体RNA加工19）蛋白质表达的下调导致有效降低SCD1（硬脂酰CoA去饱和酶-1），关键脂肪生成酶及其下游三酰基甘油合成酶DGAT-1（二酰甘油酰基转移酶 - 1）和GPAT（甘油 - 磷酸酰基转移酶），以及中性脂质的细胞内含量，这是治疗肥胖症的主要目标。

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