发明申请
- 专利标题： Pancreatic cancer associated antigen, antibody thereto, and diagnostic and treatment methods
- 专利标题（中）： 胰腺癌相关抗原，抗体及其诊断和治疗方法
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申请号： US10542239申请日： 2004-01-16
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公开(公告)号： US20060258841A1公开(公告)日： 2006-11-16
- 发明人: Josef Michl , Stefan Bradu , Raquib Hannan , Matthew Pincus
- 申请人： Josef Michl , Stefan Bradu , Raquib Hannan , Matthew Pincus
- 国际申请： PCT/US04/01196 WO 20040116
- 主分类号： C07K14/82
- IPC分类号： C07K14/82 ; C07K16/30
摘要：
The present invention is directed to an antigen found on the surface of rat and human pancreatic cancer cells and provides antibodies of high specificity and selectivity to this antigen as well as hybridomas secreting the subject antibodies. Methods for both the diagnosis and treatment of pancreatic cancer are also provided. This tissue marker of pancreatic adenocarcinoma, an approximately 43.5 kD surface membrane protein designated PaCa-Ag1, is completely unexpressed in normal pancreas but abundantly expressed in pancreatic carcinoma cells. Moreover, a soluble form of PaCa-Ag1 exists, having a molecular weight about 36 to about 38 kD, that is readily identified in sera and other body fluids of pancreatic cancer patients, using a subject antibody.
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