公开(公告)号：US20160083475A1

公开(公告)日：2016-03-24

申请号：US14492408

申请日：2014-09-22

申请人： Josef Michl ,  Stefan M. Bradu ,  Raquib Hannan ,  Matthew R. Pincus

发明人： Josef Michl ,  Stefan M. Bradu ,  Raquib Hannan ,  Matthew R. Pincus

IPC分类号： C07K16/30 ,  A61K47/48 ,  G01N33/574

CPC分类号： C07K16/303 ,  A61K47/6817 ,  A61K47/6859 ,  A61K51/1057 ,  A61K2039/505 ,  C07K14/47 ,  C07K2317/24 ,  C07K2317/734 ,  G01N33/57438 ,  G01N2333/705

摘要： The present invention is directed to an antigen found on the surface of rat and human pancreatic cancer cells and provides antibodies of high specificity and selectivity to this antigen as well as hybridomas secreting the subject antibodies. Methods for both the diagnosis and treatment of pancreatic cancer are also provided. This tissue marker of pancreatic adenocarcinoma, an approximately 43.5 kD surface membrane protein designated PaCa-Ag1, is completely unexpressed in normal pancreas but abundantly expressed in pancreatic carcinoma cells. Moreover, a soluble form of PaCa-Ag1 exists, having a molecular weight about 36 to about 38 kD, that is readily identified in sera and other body fluids of pancreatic cancer patients, using a subject antibody.

摘要翻译： 本发明涉及在大鼠和人胰腺癌细胞表面上发现的抗原，并且提供对该抗原以及分泌本发明抗体的杂交瘤具有高特异性和选择性的抗体。 还提供了胰腺癌诊断和治疗方法。 胰腺腺癌组织标志物，一种约43.5 kD的表皮膜蛋白，称为PaCa-Ag1，在正常胰腺中完全未表达，但在胰腺癌细胞中大量表达。 此外，使用受试抗体，存在可溶形式的PaCa-Ag1，其分子量约36至约38kD，其易于在胰腺癌患者的血清和其它体液中鉴定。

公开(公告)号：US20170022288A9

公开(公告)日：2017-01-26

申请号：US14492408

申请日：2014-09-22

申请人： Josef Michl ,  Stefan M. Bradu ,  Raquib Hannan ,  Matthew R. Pincus

发明人： Josef Michl ,  Stefan M. Bradu ,  Raquib Hannan ,  Matthew R. Pincus

IPC分类号： C07K16/30 ,  A61K47/48 ,  G01N33/574

CPC分类号： C07K16/303 ,  A61K47/6817 ,  A61K47/6859 ,  A61K51/1057 ,  A61K2039/505 ,  C07K14/47 ,  C07K2317/24 ,  C07K2317/734 ,  G01N33/57438 ,  G01N2333/705

摘要： The present invention is directed to an antigen found on the surface of rat and human pancreatic cancer cells and provides antibodies of high specificity and selectivity to this antigen as well as hybridomas secreting the subject antibodies. Methods for both the diagnosis and treatment of pancreatic cancer are also provided. This tissue marker of pancreatic adenocarcinoma, an approximately 43.5 kD surface membrane protein designated PaCa-Ag1, is completely unexpressed in normal pancreas but abundantly expressed in pancreatic carcinoma cells. Moreover, a soluble form of PaCa-Ag1 exists, having a molecular weight about 36 to about 38 kD, that is readily identified in sera and other body fluids of pancreatic cancer patients, using a subject antibody.

摘要翻译： 本发明涉及在大鼠和人胰腺癌细胞表面上发现的抗原，并且提供对该抗原以及分泌本发明抗体的杂交瘤具有高特异性和选择性的抗体。 还提供了胰腺癌诊断和治疗方法。 胰腺腺癌组织标志物，一种约43.5 kD的表皮膜蛋白，称为PaCa-Ag1，在正常胰腺中完全未表达，但在胰腺癌细胞中大量表达。 此外，使用受试抗体，存在可溶形式的PaCa-Ag1，其分子量约36至约38kD，其易于在胰腺癌患者的血清和其它体液中鉴定。

公开(公告)号：US20060258841A1

公开(公告)日：2006-11-16

申请号：US10542239

申请日：2004-01-16

申请人： Josef Michl ,  Stefan Bradu ,  Raquib Hannan ,  Matthew Pincus

发明人： Josef Michl ,  Stefan Bradu ,  Raquib Hannan ,  Matthew Pincus

IPC分类号： C07K14/82 ,  C07K16/30

CPC分类号： C07K16/303 ,  A61K47/6817 ,  A61K47/6859 ,  A61K51/1057 ,  A61K2039/505 ,  C07K14/47 ,  C07K2317/24 ,  C07K2317/734 ,  G01N33/57438 ,  G01N2333/705

摘要： The present invention is directed to an antigen found on the surface of rat and human pancreatic cancer cells and provides antibodies of high specificity and selectivity to this antigen as well as hybridomas secreting the subject antibodies. Methods for both the diagnosis and treatment of pancreatic cancer are also provided. This tissue marker of pancreatic adenocarcinoma, an approximately 43.5 kD surface membrane protein designated PaCa-Ag1, is completely unexpressed in normal pancreas but abundantly expressed in pancreatic carcinoma cells. Moreover, a soluble form of PaCa-Ag1 exists, having a molecular weight about 36 to about 38 kD, that is readily identified in sera and other body fluids of pancreatic cancer patients, using a subject antibody.

摘要翻译： 本发明涉及在大鼠和人胰腺癌细胞表面上发现的抗原，并且提供对该抗原以及分泌本发明抗体的杂交瘤具有高特异性和选择性的抗体。 还提供了胰腺癌诊断和治疗方法。 胰腺腺癌组织标志物，一种约43.5 kD的表皮膜蛋白，称为PaCa-Ag1，在正常胰腺中完全未表达，但在胰腺癌细胞中大量表达。 此外，使用受试抗体，存在可溶形式的PaCa-Ag1，其分子量约36至约38kD，其易于在胰腺癌患者的血清和其它体液中鉴定。