Invention Application
- Patent Title: Synthesis of CCR5 antagonists
- Patent Title (中): CCR5拮抗剂的合成
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Application No.: US11326154Application Date: 2006-01-05
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Publication No.: US20060258863A1Publication Date: 2006-11-16
- Inventor: Xiongwei Shi , Man Zhu , William Leong , Vilas Dahanukar , Ilia Zavialov , Cecilia Proletei , Shannon Zhao , Hong-Chang Lee , Yi Liu , Hoa Nguyen , Wenxue Wu , Bosco D'Sa , Feng Liang , Loc Tran
- Applicant: Xiongwei Shi , Man Zhu , William Leong , Vilas Dahanukar , Ilia Zavialov , Cecilia Proletei , Shannon Zhao , Hong-Chang Lee , Yi Liu , Hoa Nguyen , Wenxue Wu , Bosco D'Sa , Feng Liang , Loc Tran
- Assignee: Schering Corporation
- Current Assignee: Schering Corporation
- Main IPC: C07D403/14
- IPC: C07D403/14
Abstract:
The present invention is directed to the synthesis of 4-[4-[(R)-[1-[cyclopropylsulfonyl)-4-piperidinyl](3-fluorophenyl)methyl]-3(S)-methyl-1-piperazinyl]-1-[(4,6-dimethyl-5-pyrimidinyl)carbonyl]-4-methylpiperidine], and intermediates therefor from readily available starting materials by a novel route.
Public/Granted literature
- US07728135B2 Synthesis of CCR5 receptor antagonists Public/Granted day:2010-06-01
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