A method of determining a center of curvature of the spherical outer surface of an object using a computer system is provided. The method includes defining at least one contact region on the spherical outer surface in a plane substantially tangential to a circumference thereof and a first reference axis normal to said plane. Spatial coordinates of at least one of a first and a second geometric parameter are determined, the first geometric parameter including at least two points located on the spherical outer surface and the second geometric parameter including a second reference axis normal to the spherical outer surface. The center of curvature of the spherical outer surface is then calculated using the first reference axis and at least one of the first and second geometric parameters. An associated system and calibration device is also provided.