发明申请
- 专利标题： Mutations in the Bcr-Abl tyrosine kinase associated with resistance to STI-571
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申请号： US11485023申请日： 2006-07-12
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公开(公告)号： US20060269956A1公开(公告)日： 2006-11-30
- 发明人: Charles Sawyers , Mercedes Gorre , Neil Shah , John Nicoll
- 申请人： Charles Sawyers , Mercedes Gorre , Neil Shah , John Nicoll
- 主分类号： C12Q1/68
- IPC分类号： C12Q1/68 ; G01N33/574
摘要：
The invention described herein relates to novel genes and their encoded proteins, termed Mutants Associated with Resistance to STI-571 (e.g., T315I Bcr-Abl), and to diagnostic and therapeutic methods and compositions useful in the management of various cancers that express MARS. The invention further provides methods for identifying molecules that bind to and/or modulate the functional activity of MARS.
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