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1.发明申请MUTATIONS IN THE BCR-ABL TYROSINE KINASE ASSOCIATED WITH RESISTANCE TO STI-571 审中-公开与STI-571相关的BCR-ABL酪氨酸激酶相关突变公开(公告)号：US20100248241A1
公开(公告)日：2010-09-30
申请号：US12730623
申请日：2010-03-24
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C07K14/82 , C12Q1/485 , C12Q2600/106 , C12Q2600/136 , C12Q2600/156 , G01N33/5748 , G01N2333/912 , G01N2500/10 , G01N2800/52
摘要： The invention described herein relates to novel genes and their encoded proteins, termed Mutants Associated with Resistance to STI-571 (e.g., T315I Bcr-Abl), and to diagnostic and therapeutic methods and compositions useful in the management of various cancers that express MARS. The invention further provides methods for identifying molecules that bind to and/or modulate the functional activity of MARS.
摘要翻译： 本文描述的本发明涉及新型基因及其编码的蛋白质，称为与STI-571（例如，T315I Bcr-Abl）抗性相关的突变体，以及可用于管理表达MARS的各种癌症的诊断和治疗方法和组合物。 本发明还提供用于鉴定结合和/或调节MARS的功能活性的分子的方法。
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2.发明授权Mutations in the Bcr-Abl tyrosine kinase associated with resistance to STI-571 有权与STI-571抗性相关的Bcr-Abl酪氨酸激酶突变公开(公告)号：US07521175B2
公开(公告)日：2009-04-21
申请号：US10171889
申请日：2002-06-14
IPC分类号： C12Q1/68 , G01N33/574 , C12N9/12
CPC分类号： C12Q1/6886 , C07K14/82 , C12Q1/485 , C12Q2600/106 , C12Q2600/136 , C12Q2600/156 , G01N33/5748 , G01N2333/912 , G01N2500/10 , G01N2800/52
摘要： The invention described herein relates to novel genes and their encoded proteins, termed Mutants Associated with Resistance to STI-571 (e.g., T315I Bcr-Abl), and to diagnostic and therapeutic methods and compositions useful in the management of various cancers that express MARS. The invention further provides methods for identifying molecules that bind to and/or modulate the functional activity of MARS.
摘要翻译： 本文描述的本发明涉及新型基因及其编码的蛋白质，称为与STI-571（例如，T315I Bcr-Abl）抗性相关的突变体，以及可用于管理表达MARS的各种癌症的诊断和治疗方法和组合物。 本发明还提供用于鉴定结合和/或调节MARS的功能活性的分子的方法。
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公开(公告)号：US09056924B2
公开(公告)日：2015-06-16
申请号：US12080596
申请日：2008-04-04
CPC分类号： C12Q1/6886 , C07K14/82 , C12Q1/485 , C12Q2600/106 , C12Q2600/136 , C12Q2600/156 , G01N33/5748 , G01N2333/912 , G01N2500/10 , G01N2800/52
摘要： The invention described herein relates to novel genes and their encoded proteins, termed Mutants Associated with Resistance to STI-571 (e.g., T315I Bcr-Abl), and to diagnostic and therapeutic methods and compositions useful in the management of various cancers that express MARS. The invention further provides methods for identifying molecules that bind to and/or modulate the functional activity of MARS.
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公开(公告)号：USD513787S1
公开(公告)日：2006-01-24
申请号：US29201345
申请日：2004-03-15
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公开(公告)号：US09085644B2
公开(公告)日：2015-07-21
申请号：US13547954
申请日：2012-07-12
CPC分类号： C12Q1/6886 , C07K14/82 , C12Q1/485 , C12Q2600/106 , C12Q2600/136 , C12Q2600/156 , G01N33/5748 , G01N2333/912 , G01N2500/10 , G01N2800/52
摘要： The invention described herein relates to novel genes and their encoded proteins, termed Mutants Associated with Resistance to STI-571 (e.g., T315I Bcr-Abl), and to diagnostic and therapeutic methods and compositions useful in the management of various cancers that express MARS. The invention further provides methods for identifying molecules that bind to and/or modulate the functional activity of MARS.
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6.发明授权Mutations in the Bcr-Abl tyrosine kinase associated with resistance to STI-571 有权与STI-571抗性相关的Bcr-Abl酪氨酸激酶突变公开(公告)号：US08697348B2
公开(公告)日：2014-04-15
申请号：US11485023
申请日：2006-07-12
IPC分类号： C12Q1/00 , C12Q1/68 , G01N33/53 , G01N33/574 , G01N33/00
CPC分类号： C12Q1/6886 , C07K14/82 , C12Q1/485 , C12Q2600/106 , C12Q2600/136 , C12Q2600/156 , G01N33/5748 , G01N2333/912 , G01N2500/10 , G01N2800/52
摘要： The invention described herein relates to novel genes and their encoded proteins, termed Mutants Associated with Resistance to STI-571 (e.g., T315I Bcr-Abl), and to diagnostic and therapeutic methods and compositions useful in the management of various cancers that express MARS. The invention further provides methods for identifying molecules that bind to and/or modulate the functional activity of MARS.
摘要翻译： 本文描述的本发明涉及新型基因及其编码的蛋白质，称为与STI-571（例如，T315I Bcr-Abl）抗性相关的突变体，以及可用于管理表达MARS的各种癌症的诊断和治疗方法和组合物。 本发明还提供用于鉴定结合和/或调节MARS的功能活性的分子的方法。
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公开(公告)号：US20060269956A1
公开(公告)日：2006-11-30
申请号：US11485023
申请日：2006-07-12
申请人： Charles Sawyers , Mercedes Gorre , Neil Shah , John Nicoll
发明人： Charles Sawyers , Mercedes Gorre , Neil Shah , John Nicoll
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： C12Q1/6886 , C07K14/82 , C12Q1/485 , C12Q2600/106 , C12Q2600/136 , C12Q2600/156 , G01N33/5748 , G01N2333/912 , G01N2500/10 , G01N2800/52
摘要： The invention described herein relates to novel genes and their encoded proteins, termed Mutants Associated with Resistance to STI-571 (e.g., T315I Bcr-Abl), and to diagnostic and therapeutic methods and compositions useful in the management of various cancers that express MARS. The invention further provides methods for identifying molecules that bind to and/or modulate the functional activity of MARS.
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8.发明授权Mutations in the Bcr-Abl tyrosine kinase associated with resistance to ST1-571 有权与ST1-571抗性相关的Bcr-Abl酪氨酸激酶突变公开(公告)号：US08586291B2
公开(公告)日：2013-11-19
申请号：US12381448
申请日：2009-03-11
IPC分类号： C12Q1/00 , G01N33/574
CPC分类号： C12Q1/6886 , C07K14/82 , C12Q1/485 , C12Q2600/106 , C12Q2600/136 , C12Q2600/156 , G01N33/5748 , G01N2333/912 , G01N2500/10 , G01N2800/52
摘要： The invention described herein relates to novel genes and their encoded proteins, termed Mutants Associated with Resistance to STI-571 (e.g., T315I Bcr-Abl), and to diagnostic and therapeutic methods and compositions useful in the management of various cancers that express MARS. The invention further provides methods for identifying molecules that bind to and/or modulate the functional activity of MARS.
摘要翻译： 本文描述的本发明涉及新型基因及其编码的蛋白质，称为与STI-571（例如，T315I Bcr-Abl）抗性相关的突变体，以及可用于管理表达MARS的各种癌症的诊断和治疗方法和组合物。 本发明还提供用于鉴定结合和/或调节MARS的功能活性的分子的方法。
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公开(公告)号：US20120282622A1
公开(公告)日：2012-11-08
申请号：US13547954
申请日：2012-07-12
IPC分类号： C12Q1/68 , G01N33/573
CPC分类号： C12Q1/6886 , C07K14/82 , C12Q1/485 , C12Q2600/106 , C12Q2600/136 , C12Q2600/156 , G01N33/5748 , G01N2333/912 , G01N2500/10 , G01N2800/52
摘要： The invention described herein relates to novel genes and their encoded proteins, termed Mutants Associated with Resistance to STI-571 (e.g., T315I Bcr-Abl), and to diagnostic and therapeutic methods and compositions useful in the management of various cancers that express MARS. The invention further provides methods for identifying molecules that bind to and/or modulate the functional activity of MARS.
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10.发明申请MUTATIONS IN THE BCR-ABL TYROSINE KINASE ASSOCIATED WITH RESISTANCE TO STI-571 审中-公开与STI-571相关的BCR-ABL酪氨酸激酶相关突变公开(公告)号：US20120021425A1
公开(公告)日：2012-01-26
申请号：US13248921
申请日：2011-09-29
IPC分类号： C12Q1/68 , G01N33/573
CPC分类号： C12Q1/6886 , C07K14/82 , C12Q1/485 , C12Q2600/106 , C12Q2600/136 , C12Q2600/156 , G01N33/5748 , G01N2333/912 , G01N2500/10 , G01N2800/52
摘要： The invention described herein relates to novel genes and their encoded proteins, termed Mutants Associated with Resistance to STI-571 (e.g., T315I Bcr-Abl), and to diagnostic and therapeutic methods and compositions useful in the management of various cancers that express MARS. The invention further provides methods for identifying molecules that bind to and/or modulate the functional activity of MARS.
摘要翻译： 本文描述的本发明涉及新型基因及其编码的蛋白质，称为与STI-571（例如，T315I Bcr-Abl）抗性相关的突变体，以及可用于管理表达MARS的各种癌症的诊断和治疗方法和组合物。 本发明还提供用于鉴定结合和/或调节MARS的功能活性的分子的方法。
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