- 专利标题： Process for preparing (2R,3S)-1,2-epoxy-3-(protected)amino-4-substituted butane and intermediates thereof
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申请号： US11365275申请日： 2006-03-01
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公开(公告)号： US20060270012A1公开(公告)日： 2006-11-30
- 发明人: Nigel Bowers , Paul Skonezny , Gregory Stein , Thomas Franceschini , Shu-Jen Chiang , Wendy Anderson , Li You , Zizhou Xing
- 申请人： Nigel Bowers , Paul Skonezny , Gregory Stein , Thomas Franceschini , Shu-Jen Chiang , Wendy Anderson , Li You , Zizhou Xing
- 主分类号： C12P7/02
- IPC分类号： C12P7/02
摘要：
The present invention relates to a process for preparing (2R,3S)-1-halo-2-hydroxy-3-(protected)amino-4-substituted butane comprising contacting a mutagenized Rhodococcus erythropolis having ATCC deposit no. PTA-6648 with (3S)-1-halo-2-oxo-3-(protected)amino-4-substituted butane substrate. The present invention also relates to a process comprising mixing (2R,3S)-1-halo-2-hydroxy-3-(protected)amino-4-substituted butane with at least one base in the presence of at least one solvent to produce a reaction mixture containing (2R,3S)-1,2-epoxy-3-(protected)amino-4-substituted butane. The present invention further relates to a process comprising crystallizing the (2R,3S)-1,2-epoxy-3-(protected)amino-4-substituted butane out of the reaction mixture by concurrently adding water and the reaction mixture together. The present invention is also directed to a mutagenized Rhodococcus erythropolis having ATCC deposit no. PTA-6648.
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