In response to execution of program code, a control register within scrubbing logic in a local coherency domain is initialized with at least a target address of a target memory block. In response to the initialization, the scrubbing logic issues to at least one cache hierarchy in a remote coherency domain a domain indication scrubbing request targeting a target memory block that may be cached by the at least one cache hierarchy. In response to receipt of a coherency response indicating that the target memory block is not cached in the remote coherency domain, a domain indication in the local coherency domain is updated to indicate that the target memory block is cached, if at all, only within the local coherency domain.