发明申请
- 专利标题： Factor VII or VIIa Polypeptide Variants
- 专利标题（中）： 因子VII或VIIa多肽变体
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申请号： US11381718申请日： 2006-05-04
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公开(公告)号： US20060276377A1公开(公告)日： 2006-12-07
- 发明人: Jesper Haaning , Kim Andersen
- 申请人： Jesper Haaning , Kim Andersen
- 专利权人： Maxygen Holdings, Ltd.
- 当前专利权人： Maxygen Holdings, Ltd.
- 主分类号： A61K38/37
- IPC分类号： A61K38/37 ; C07K14/745 ; A61K38/16 ; C07H21/04 ; C12P21/04
摘要：
The present invention relates to novel polypeptide variants of factor VII (FVII) or factor VIIa (FVIIa) polypeptides, where said variants comprise an amino acid substitution in position 10 and 32 and where said variants further comprise a sugar moiety covalently attached to an introduced in vivo N-glycosylation site located outside of the Gla domain. Such polypeptide variants are useful in therapy, in particular for the treatment of a variety of coagulation-related disorders, such as trauma.
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