发明申请
- 专利标题: Hydrazone derivative
- 专利标题(中): 腙衍生物
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申请号: US10551414申请日: 2004-03-31
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公开(公告)号: US20060276433A1公开(公告)日: 2006-12-07
- 发明人: Keiichi Kawagoe , Kayoko Motoki , Takashi Odagiri , Nobuyuki Suzuki , Chun-Jen Chen , Tetsuya Mimura
- 申请人: Keiichi Kawagoe , Kayoko Motoki , Takashi Odagiri , Nobuyuki Suzuki , Chun-Jen Chen , Tetsuya Mimura
- 优先权: JP2003-94257 20030331
- 国际申请: PCT/JP04/04607 WO 20040331
- 主分类号: A61K31/695
- IPC分类号: A61K31/695 ; A61K31/537 ; A61K31/445 ; A61K31/40 ; C07D211/56 ; C07F7/00 ; C07F7/10
摘要:
A compound represented by the following formula (I): wherein R1 represents hydrogen, aryl which may have a substituent, a saturated or unsaturated 5- to 7-membered heterocyclic group which may have a substituent, etc.; R2 represents hydrogen, aryl which may have a substituent, a saturated or unsaturated 5- to 7-membered heterocyclic group which may have a substituent, etc.; R3 represents hydrogen, etc.; Ar represents a divalent group derived from aromatic hydrocarbon, etc.; X represents a single bond, linear or branched alkylene having from 1 to 3 carbon atoms which may have a substituent, etc.; and G represents halogen, a saturated or unsaturated 5- or 6-membered cyclic hydrocarbon group which may have a substituent, a saturated or unsaturated 5- to 7-membered heterocyclic group which may have a substituent, etc., a salt thereof or a solvate thereof; and an agent for inhibiting aggregation and/or deposition of an amyloid protein or an amyloid-like protein, which comprises the compound, a salt thereof or a solvate thereof.
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