发明申请
US20060280742A1 METHODS OF INHIBITING TNF-ALPHA IN PATIENTS WITH CROHN'S DISEASE
失效
抑制患有CROHN病的患者TNF-α的方法
- 专利标题: METHODS OF INHIBITING TNF-ALPHA IN PATIENTS WITH CROHN'S DISEASE
- 专利标题(中): 抑制患有CROHN病的患者TNF-α的方法
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申请号: US11297655申请日: 2005-12-08
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公开(公告)号: US20060280742A1公开(公告)日: 2006-12-14
- 发明人: Junming Le , Jan Vilcek , Peter Daddona , John Ghrayeb , David Knight , Scott Siegel
- 申请人: Junming Le , Jan Vilcek , Peter Daddona , John Ghrayeb , David Knight , Scott Siegel
- 主分类号: A61K39/395
- IPC分类号: A61K39/395 ; A61K31/60 ; A61K31/192 ; A61K31/485 ; A61K31/405
摘要:
Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in vivo diagnosis and therapy of a number of TNFα-mediated pathologies and conditions, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.