公开(公告)号：US20100249032A1

公开(公告)日：2010-09-30

申请号：US12718147

申请日：2010-03-05

Applicant: George A. Heavner ,  David M. Knight ,  John Ghrayeb ,  Bernard J. Scallon ,  Thomas C. Nesspor ,  Chichi Huang

Inventor： George A. Heavner ,  David M. Knight ,  John Ghrayeb ,  Bernard J. Scallon ,  Thomas C. Nesspor ,  Chichi Huang

IPC: A61K38/10 ,  C07H21/04 ,  C07K7/00 ,  C07K16/00 ,  A61K38/08 ,  A61P19/00 ,  A61P9/00 ,  A61P5/00 ,  A61P3/00 ,  A61P1/00 ,  A61P15/00 ,  A61P17/00 ,  A61P21/00 ,  A61P13/00 ,  A61P25/00 ,  A61P11/00 ,  A61P27/16 ,  A61P31/00 ,  A61P37/00

CPC classification number: C07K14/505 ,  Y10S435/972

Abstract: The present invention relates to at least one novel human EPO mimetic hinge core mimetibody or specified portion or variant, including isolated nucleic acids that encode at least one EPO mimetic hinge core mimetibody or specified portion or variant, EPO mimetic hinge core mimetibody or specified portion or variants, vectors, host cells, transgenic animals or plants, and methods of making and using thereof, including therapeutic compositions, methods and devices.

Abstract translation: 本发明涉及至少一种新的人EPO模拟铰链核心模拟体或特定部分或变体，包括编码至少一个EPO模拟铰链核心模拟体或特定部分或变体的分离的核酸，EPO模拟铰链核心模拟体或特定部分或 变体，载体，宿主细胞，转基因动物或植物，以及其制备和使用方法，包括治疗组合物，方法和装置。

公开(公告)号：US20080033149A1

公开(公告)日：2008-02-07

申请号：US11891036

申请日：2007-08-08

Applicant: Junming Le ,  Jan Vilcek ,  Peter Daddona ,  John Ghrayeb ,  David Knight ,  Scott Siegel

Inventor： Junming Le ,  Jan Vilcek ,  Peter Daddona ,  John Ghrayeb ,  David Knight ,  Scott Siegel

IPC: C07K16/46

CPC classification number: A61K39/3955 ,  A61K31/167 ,  A61K31/192 ,  A61K31/196 ,  A61K31/405 ,  A61K31/485 ,  A61K31/519 ,  A61K31/573 ,  A61K38/00 ,  A61K45/00 ,  A61K45/06 ,  A61K2039/505 ,  C07K14/525 ,  C07K16/241 ,  C07K16/30 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/00 ,  A61K2300/00

Abstract: Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in vivo diagnosis and therapy of a number of TNFα-mediated pathologies and conditions, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.

Abstract translation: 抗TNF抗体，其对人肿瘤坏死因子-α（TNFalpha）特异性的片段和区域，并且可用于许多TNFα介导的病理学和病症的体内诊断和治疗，以及编码鼠和嵌合体的多核苷酸 提供了免疫测定和免疫治疗方法中的抗体，抗体的制备方法，抗TNF抗体的使用方法或其片段，区域或衍生物。

公开(公告)号：US20070298040A1

公开(公告)日：2007-12-27

申请号：US11401391

申请日：2006-04-10

Applicant: Junming Le ,  Jan Vilcek ,  Peter Daddona ,  John Ghrayeb ,  David Knight ,  Scott Siegel

Inventor： Junming Le ,  Jan Vilcek ,  Peter Daddona ,  John Ghrayeb ,  David Knight ,  Scott Siegel

IPC: A61K39/395

CPC classification number: C07K16/241 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/76 ,  Y02A50/412

Abstract: Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in vivo diagnosis and therapy of a number of TNFαx-mediated pathologies and conditions, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.

Abstract translation: 抗TNF抗体，其对人肿瘤坏死因子-α（TNFalpha）特异性的片段和区域，并且可用于许多TNFα介导的病理学和病症的体内诊断和治疗，以及编码鼠和嵌合体的多核苷酸 提供了免疫测定和免疫治疗方法中的抗体，抗体的制备方法，抗TNF抗体的使用方法或其片段，区域或衍生物。

公开(公告)号：US07276239B2

公开(公告)日：2007-10-02

申请号：US11314941

申请日：2005-12-20

Applicant: Junming Le ,  Jan Vilcek ,  Peter Daddona ,  John Ghrayeb ,  David Knight ,  Scott Siegel

Inventor： Junming Le ,  Jan Vilcek ,  Peter Daddona ,  John Ghrayeb ,  David Knight ,  Scott Siegel

IPC: A61K39/395 ,  C07K16/24

CPC classification number: A61K39/3955 ,  A61K31/167 ,  A61K31/192 ,  A61K31/196 ,  A61K31/405 ,  A61K31/485 ,  A61K31/519 ,  A61K31/573 ,  A61K38/00 ,  A61K45/00 ,  A61K45/06 ,  A61K2039/505 ,  C07K14/525 ,  C07K16/241 ,  C07K16/30 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/00 ,  A61K2300/00

Abstract: Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in vivo diagnosis and therapy of a number of TNFα-mediated pathologies and conditions, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.

Abstract translation: 抗TNF抗体，其对人肿瘤坏死因子-α（TNFalpha）特异性的片段和区域，并且可用于许多TNFα介导的病理学和病症的体内诊断和治疗，以及编码鼠和嵌合体的多核苷酸 提供了免疫测定和免疫治疗方法中的抗体，抗体的制备方法，抗TNF抗体的使用方法或其片段，区域或衍生物。

公开(公告)号：US20070196373A1

公开(公告)日：2007-08-23

申请号：US11501162

申请日：2006-08-08

Applicant: Junming Le ,  Jan Vilcek ,  Peter Daddona ,  John Ghrayeb ,  David Knight ,  Scott Siegel ,  David Shealy

Inventor： Junming Le ,  Jan Vilcek ,  Peter Daddona ,  John Ghrayeb ,  David Knight ,  Scott Siegel ,  David Shealy

IPC: A61K39/395

CPC classification number: C07K16/241 ,  A61K2039/505 ,  C07K16/30 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/00 ,  Y02A50/412

Abstract: Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in vivo diagnosis and therapy of a number of TNFα-mediated pathologies and conditions, including ankylosing spondylitis, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.

Abstract translation: 抗TNF抗体，其对人肿瘤坏死因子-α（TNFalpha）特异性的片段和区域，并且可用于许多TNFα介导的病理学和病症（包括强直性脊柱炎）的体内诊断和治疗，以及编码 提供了鼠和嵌合抗体，免疫测定和免疫治疗方法中产生抗体的方法，抗TNF抗体或其片段，区域或衍生物的使用方法。

公开(公告)号：US07223396B2

公开(公告)日：2007-05-29

申请号：US10319011

申请日：2002-12-12

Applicant: Junming Le ,  Jan Vilcek ,  Peter Daddona ,  John Ghrayeb ,  David Knight ,  Scott Siegel

Inventor： Junming Le ,  Jan Vilcek ,  Peter Daddona ,  John Ghrayeb ,  David Knight ,  Scott Siegel

IPC: A61K39/395 ,  C07K16/28

CPC classification number: A61K39/3955 ,  A61K31/167 ,  A61K31/192 ,  A61K31/196 ,  A61K31/405 ,  A61K31/485 ,  A61K31/519 ,  A61K31/573 ,  A61K38/00 ,  A61K45/00 ,  A61K45/06 ,  A61K2039/505 ,  C07K14/525 ,  C07K16/241 ,  C07K16/30 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/00 ,  A61K2300/00

Abstract: Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful in vivo diagnosis and therapy of a number of TNFα-mediated pathologies and conditions, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.

Abstract translation: 抗TNF抗体，其对人肿瘤坏死因子-α（TNFalpha）特异性的片段和区域，并且可用于许多TNFα介导的病理学和病症的体内诊断和治疗，以及编码鼠和嵌合体的多核苷酸 提供了免疫测定和免疫治疗方法中的抗体，抗体的制备方法，抗TNF抗体的使用方法或其片段，区域或衍生物。

公开(公告)号：US07135178B2

公开(公告)日：2006-11-14

申请号：US10176460

申请日：2002-06-20

Applicant: Junming Le ,  Jan Vilcek ,  Peter Daddona ,  John Ghrayeb ,  David Knight ,  Scott Siegel

Inventor： Junming Le ,  Jan Vilcek ,  Peter Daddona ,  John Ghrayeb ,  David Knight ,  Scott Siegel

IPC: A61K39/395 ,  C07K16/28

CPC classification number: A61K39/3955 ,  A61K31/167 ,  A61K31/192 ,  A61K31/196 ,  A61K31/405 ,  A61K31/485 ,  A61K31/519 ,  A61K31/573 ,  A61K38/00 ,  A61K45/00 ,  A61K45/06 ,  A61K2039/505 ,  C07K14/525 ,  C07K16/241 ,  C07K16/30 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/00 ,  A61K2300/00

Abstract: Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-α (TNFα) and are useful for therapy of TNFα-mediated pathologies and conditions, including vascular inflammatory pathologies.

Abstract translation: 抗TNF抗体，其对人肿瘤坏死因子-α（TNFalpha）特异性的片段和区域，可用于治疗TNFα介导的病理和病症，包括血管炎症病理。

公开(公告)号：US20060140946A1

公开(公告)日：2006-06-29

申请号：US11143926

申请日：2005-06-02

Applicant: Junming Le ,  Jan Vilcek ,  Peter Daddona ,  John Ghrayeb ,  David Knight ,  Scott Siegel

Inventor： Junming Le ,  Jan Vilcek ,  Peter Daddona ,  John Ghrayeb ,  David Knight ,  Scott Siegel

IPC: A61K39/395 ,  C07K16/24

CPC classification number: C07K14/525 ,  A61K38/00 ,  A61K2039/505 ,  C07K16/241 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/00

Abstract: Anti-TNF antibodies and anti-TNF peptides, specific for tumor necrosis factor (TNF) are useful for in vivo diagnosis and therapy of a number of TNF-mediated pathologies and conditions, as well as polynucleotides coding for anti-TNF murine and chimeric antibodies, peptides, methods of making and using the antibody or peptides in immunoassays and immuno-therapeutic approaches are provided, where the anti-TNF peptide is selected from a soluble portion of TNF receptor, an anti-TNF antibody or structural analog thereof.

Abstract translation: 特异于肿瘤坏死因子（TNF）的抗TNF抗体和抗TNF肽可用于许多TNF介导的病理学和病症的体内诊断和治疗，以及编码抗TNF鼠和嵌合抗体的多核苷酸 提供肽，免疫测定法和免疫治疗方法中制备和使用抗体或肽的方法，其中抗TNF肽选自TNF受体的可溶性部分，抗TNF抗体或其结构类似物。

公开(公告)号：US5134227A

公开(公告)日：1992-07-28

申请号：US312139

申请日：1989-02-17

Applicant: Nancy T. Chang ,  John Ghrayeb

Inventor： Nancy T. Chang ,  John Ghrayeb

IPC: A61K38/00 ,  C07K14/16 ,  C12N15/49 ,  G01N33/569

CPC classification number: C07K14/005 ,  G01N33/56988 ,  A61K38/00 ,  C12N2740/16222

Abstract: DNA encoding recombinant, immunoreactive, chimeric HTLV-III core proteins and methods of producing these proteins are described.

Abstract translation: 描述了编码重组，免疫反应性，嵌合HTLV-III核心蛋白质的DNA和产生这些蛋白质的方法。

公开(公告)号：US4963497A

公开(公告)日：1990-10-16

申请号：US920780

申请日：1986-10-20

Applicant: Flossie Wong-Staal ,  Pranab K. Chanda ,  John Ghrayeb

Inventor： Flossie Wong-Staal ,  Pranab K. Chanda ,  John Ghrayeb

IPC: A61K38/00 ,  C07K14/16 ,  C07K16/10 ,  C12N15/48

CPC classification number: C07K14/005 ,  C07K16/10 ,  A61K38/00 ,  C12N2740/16322

Abstract: The present invention is the isolation and purification of a newly discovered gene of the AIDS virus, HTLV-III, which encodes a protein which is immunogenic and recognized by sera of some HTLV-III seropositive people. Furthermore, the gene is highly conserved among all known HTLV-III isolates and exhibits a polymorphism at the 3' end which distinguishes molecular clones of the HTLV-III cell line from viral genomes of related viruses (i.e., other HTLV-III isolates, LAV, ARV, etc.).

Abstract translation: 本发明是新发现的艾滋病病毒基因HTLV-III的分离和纯化，HTLV-III编码免疫原性并被一些HTLV-III血清阳性人血清识别的蛋白质。 此外，该基因在所有已知的HTLV-III分离物中是高度保守的，并且在3'末端显示多态性，其区分HTLV-III细胞系的分子克隆与相关病毒的病毒基因组（即，其他HTLV-III分离株，LAV ，ARV等）。