发明申请
US20060281699A1 Methods, compositions and compound assays for inhibiting amyloid-beta protein production
审中-公开
用于抑制淀粉样蛋白β蛋白生产的方法，组合物和化合物测定法
- 专利标题： Methods, compositions and compound assays for inhibiting amyloid-beta protein production
- 专利标题（中）： 用于抑制淀粉样蛋白β蛋白生产的方法，组合物和化合物测定法
-
申请号： US11127581申请日： 2005-05-12
-
公开(公告)号： US20060281699A1公开(公告)日： 2006-12-14
- 发明人: Pascal Merchiers , Marcel Hoffmann , Koenraad Spittaels , Wendy Laenen
- 申请人： Pascal Merchiers , Marcel Hoffmann , Koenraad Spittaels , Wendy Laenen
- 主分类号： A61K48/00
- IPC分类号： A61K48/00 ; A61K31/165 ; C40B30/06 ; C40B40/08
摘要：
A method for identifying compounds that inhibit amyloid-beta precursor protein processing in cells, comprising contacting a test compound with a PROTEASE polypeptide, or fragment thereof, and measuring a compound-PROTEASE property related to the production of amyloid-beta peptide. Cellular assays of the method measure indicators including cleaved protease substrate and/or amyloid beta peptide levels. Therapeutic methods, and pharmaceutical compositions including effective amyloid-beta precursor processing-inhibiting amounts of PROTEASE expression inhibitors, are useful for treating conditions involving cognitive impairment such as Alzheimer's disease.
信息查询
