发明申请
US20060281733A1 4-Bromo-5-(2-chloro-benzoylamino)-1h-pyrazole-3-carvoxylic acid amide derivatives and related compounds as bradykinin b1 receptor antagonists for the treatment of inflammatory diseases
失效
4-溴-5-（2-氯 - 苯甲酰基氨基）-1H-吡唑-3-羧酸酰胺衍生物和相关化合物作为缓激肽b1受体拮抗剂，用于治疗炎性疾病
- 专利标题： 4-Bromo-5-(2-chloro-benzoylamino)-1h-pyrazole-3-carvoxylic acid amide derivatives and related compounds as bradykinin b1 receptor antagonists for the treatment of inflammatory diseases
- 专利标题（中）： 4-溴-5-（2-氯 - 苯甲酰基氨基）-1H-吡唑-3-羧酸酰胺衍生物和相关化合物作为缓激肽b1受体拮抗剂，用于治疗炎性疾病
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申请号： US10555519申请日： 2004-04-30
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公开(公告)号： US20060281733A1公开(公告)日： 2006-12-14
- 发明人: Jay Tung , Albert Garofalo , Michael Pleiss , Jing Wu , David Wone , Ashley Guinn , Darren Dressen , R. Jeffrey Neitz , Jennifer Marugg , Martin Neitzel
- 申请人： Jay Tung , Albert Garofalo , Michael Pleiss , Jing Wu , David Wone , Ashley Guinn , Darren Dressen , R. Jeffrey Neitz , Jennifer Marugg , Martin Neitzel
- 国际申请： PCT/US04/13219 WO 20040430
- 主分类号： A61K31/5377
- IPC分类号： A61K31/5377 ; A61K31/5513 ; A61K31/55 ; A61K31/496 ; A61K31/4545 ; A61K31/454 ; A61K31/4152 ; C07D403/02
摘要：
Disclosed are compounds of formula I and II that are bradykinin B1 receptor antagonists and are useful for treating diseases, or relieving adverse symptoms associated with disease conditions, in mammals mediated by bradykinin B1 receptor. Certain of the compounds exhibit increased potency and are also expected to exhibit increased duration of action.
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