发明申请
US20060286112A1 Human monoclonal antibodies that bind to very late antigen-1 for the treatment of inflammation and other disorders
审中-公开
结合非常晚期抗原-1的人类单克隆抗体用于治疗炎症和其他疾病
- 专利标题： Human monoclonal antibodies that bind to very late antigen-1 for the treatment of inflammation and other disorders
- 专利标题（中）： 结合非常晚期抗原-1的人类单克隆抗体用于治疗炎症和其他疾病
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申请号： US11433924申请日： 2006-05-12
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公开(公告)号： US20060286112A1公开(公告)日： 2006-12-21
- 发明人: Sirid-Aimee Kellermann , Orit Foord , Shelley Belouski , Larry Green
- 申请人： Sirid-Aimee Kellermann , Orit Foord , Shelley Belouski , Larry Green
- 主分类号： G01N33/574
- IPC分类号： G01N33/574 ; C07H21/04 ; C12P21/06 ; A61K39/395 ; C07K16/30 ; C12N5/06
摘要：
The present invention relates to antibodies directed to very late antigen-1 (“VLA-1”) and uses of such antibodies. For example human monoclonal antibodies directed to VLA-1 are described. Isolated polynucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions (FR's) and/or complementarity determining regions (CDR's), are provided. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies are also provided.