公开(公告)号：US09580491B2

公开(公告)日：2017-02-28

申请号：US13638522

申请日：2011-03-31

申请人： Larry Green ,  Hiroaki Shizuya

发明人： Larry Green ,  Hiroaki Shizuya

IPC分类号： A01K67/00 ,  C07K16/00 ,  C12N15/85 ,  C07K16/18 ,  A01K67/027

CPC分类号： C07K16/461 ,  A01K67/0275 ,  A01K67/0278 ,  A01K2207/15 ,  A01K2217/052 ,  A01K2217/072 ,  A01K2227/105 ,  A01K2267/01 ,  C07K16/00 ,  C07K16/18 ,  C07K2317/14 ,  C07K2317/24 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/52 ,  C07K2317/522 ,  C07K2317/524 ,  C07K2317/526 ,  C07K2317/53 ,  C07K2317/56 ,  C07K2317/64 ,  C12N15/8509 ,  C12N2510/02

摘要： The invention provides non-human cells and mammals having a genome encoding chimeric antibodies and methods of producing transgenic cells and mammals. Certain aspects of the invention include chimeric antibodies, humanized antibodies, pharmaceutical compositions and kits. Certain aspects of the invention also relate to diagnostic and treatment methods using the antibodies of the invention.

摘要翻译： 本发明提供具有编码嵌合抗体的基因组的非人类细胞和哺乳动物以及产生转基因细胞和哺乳动物的方法。 本发明的某些方面包括嵌合抗体，人源化抗体，药物组合物和试剂盒。 本发明的某些方面还涉及使用本发明的抗体的诊断和治疗方法。

公开(公告)号：US09096672B2

公开(公告)日：2015-08-04

申请号：US12396313

申请日：2009-03-02

申请人： Richard Weber ,  Xiao Feng ,  Orit Foord ,  Larry Green ,  Jean M. Gudas ,  Bruce Keyt ,  Ying Liu ,  Palaniswami Rathanaswami ,  Robert Raya ,  Xiao Dong Yang ,  Jose Corvalan ,  Ian Foltz ,  Xiao-Chi Jia ,  Jaspal S. Kang ,  Chadwick T. King ,  Scott L. Klakamp ,  Qiaojuan Jane Su

发明人： Richard Weber ,  Xiao Feng ,  Orit Foord ,  Larry Green ,  Jean M. Gudas ,  Bruce Keyt ,  Ying Liu ,  Palaniswami Rathanaswami ,  Robert Raya ,  Xiao Dong Yang ,  Jose Corvalan ,  Ian Foltz ,  Xiao-Chi Jia ,  Jaspal S. Kang ,  Chadwick T. King ,  Scott L. Klakamp ,  Qiaojuan Jane Su

IPC分类号： C07K16/28 ,  A61K39/00 ,  A61K39/395 ,  A61K47/48 ,  B82Y5/00

CPC分类号： C07K16/30 ,  A61K47/6803 ,  A61K47/6849 ,  A61K47/6897 ,  A61K2039/505 ,  B82Y5/00 ,  C07K16/2863 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/77 ,  C07K2317/92 ,  Y10S435/81

摘要： The present invention relates to novel antibodies, particularly antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to the type III deletion mutant, EGFRvIII. The invention also relates to human monoclonal antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to EGFRvIII. Diagnostic and therapeutic formulations of such antibodies, and immunoconjugates thereof, are also provided.

公开(公告)号：US09085624B2

公开(公告)日：2015-07-21

申请号：US12268352

申请日：2008-11-10

申请人： Richard Weber ,  Xiao Feng ,  Orit Foord ,  Larry Green ,  Jean M. Gudas ,  Bruce Keyt ,  Ying Liu ,  Palaniswami Rathanaswami ,  Robert Raya ,  Xiao Dong Yang ,  Jose Corvalan ,  Ian Foltz ,  Xiao-Chi Jia ,  Jaspal S. Kang ,  Chadwick T. King ,  Scott L. Klakamp ,  Qiaojuan Jane Su

发明人： Richard Weber ,  Xiao Feng ,  Orit Foord ,  Larry Green ,  Jean M. Gudas ,  Bruce Keyt ,  Ying Liu ,  Palaniswami Rathanaswami ,  Robert Raya ,  Xiao Dong Yang ,  Jose Corvalan ,  Ian Foltz ,  Xiao-Chi Jia ,  Jaspal S. Kang ,  Chadwick T. King ,  Scott L. Klakamp ,  Qiaojuan Jane Su

IPC分类号： A61K39/395 ,  C07K16/28 ,  A61K39/00 ,  A61K47/48 ,  B82Y5/00

CPC分类号： C07K16/30 ,  A61K47/6803 ,  A61K47/6849 ,  A61K47/6897 ,  A61K2039/505 ,  B82Y5/00 ,  C07K16/2863 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/77 ,  C07K2317/92 ,  Y10S435/81

摘要： The present invention relates to novel antibodies, particularly antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to the type III deletion mutant, EGFRvIII. The invention also relates to human monoclonal antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to EGFRvIII. Diagnostic and therapeutic formulations of such antibodies, and immunoconjugates thereof, are also provided.

公开(公告)号：US20150197577A9

公开(公告)日：2015-07-16

申请号：US13608337

申请日：2012-09-10

申请人： Paul J. Maddon ,  Gerald P. Donovan ,  William C. Olson ,  Norbert Schuelke ,  Jason Gardner ,  Dangshe Ma ,  Jaspal S. Kang ,  Larry Green

发明人： Paul J. Maddon ,  Gerald P. Donovan ,  William C. Olson ,  Norbert Schuelke ,  Jason Gardner ,  Dangshe Ma ,  Jaspal S. Kang ,  Larry Green

IPC分类号： C07K16/40 ,  A61K51/10 ,  G01N33/574

CPC分类号： C07K16/40 ,  A61K38/1709 ,  A61K39/0011 ,  A61K39/39558 ,  A61K47/6825 ,  A61K47/6869 ,  A61K51/1072 ,  A61K51/1093 ,  A61K51/1096 ,  A61K2039/505 ,  C07K14/4748 ,  C07K16/3069 ,  C07K2317/21 ,  C07K2317/565 ,  C07K2317/622 ,  G01N33/57434

摘要： The invention includes stable multimeric, particularly dimeric, forms of PSMA protein, compositions and kits containing dimeric PSMA protein as well as methods of producing, purifying and using these compositions. Such methods include methods for eliciting or enhancing an immune response to cells expressing PSMA, including methods of producing antibodies to dimeric PSMA, as well as methods of treating cancer, such as prostate cancer.

摘要翻译： 本发明包括稳定的多聚体，特别是二聚体形式的PSMA蛋白，含有二聚体PSMA蛋白的组合物和试剂盒，以及生产，纯化和使用这些组合物的方法。 这些方法包括引发或增强对表达PSMA的细胞的免疫应答的方法，包括产生二聚体PSMA的抗体的方法以及治疗癌症的方法，例如前列腺癌。

公开(公告)号：US09073998B2

公开(公告)日：2015-07-07

申请号：US12396286

申请日：2009-03-02

申请人： Richard Weber ,  Xiao Feng ,  Orit Foord ,  Larry Green ,  Jean M. Gudas ,  Bruce Keyt ,  Ying Liu ,  Palaniswami Rathanaswami ,  Robert Raya ,  Xiao Dong Yang ,  Jose Corvalan ,  Ian Foltz ,  Xiao-Chi Jia ,  Jaspal S. Kang ,  Chadwick T. King ,  Scott L. Klakamp ,  Qiaojuan Jane Su

发明人： Richard Weber ,  Xiao Feng ,  Orit Foord ,  Larry Green ,  Jean M. Gudas ,  Bruce Keyt ,  Ying Liu ,  Palaniswami Rathanaswami ,  Robert Raya ,  Xiao Dong Yang ,  Jose Corvalan ,  Ian Foltz ,  Xiao-Chi Jia ,  Jaspal S. Kang ,  Chadwick T. King ,  Scott L. Klakamp ,  Qiaojuan Jane Su

IPC分类号： A61K47/48 ,  C07K16/28 ,  C07K14/71 ,  A61K39/395 ,  B82Y5/00 ,  A61K39/00

CPC分类号： C07K16/30 ,  A61K47/6803 ,  A61K47/6849 ,  A61K47/6897 ,  A61K2039/505 ,  B82Y5/00 ,  C07K16/2863 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/77 ,  C07K2317/92 ,  Y10S435/81

摘要： The present invention relates to novel antibodies, particularly antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to the type III deletion mutant, EGFRvIII. The invention also relates to human monoclonal antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to EGFRvIII. Diagnostic and therapeutic formulations of such antibodies, and immunoconjugates thereof, are also provided.

公开(公告)号：US20110123527A1

公开(公告)日：2011-05-26

申请号：US12993940

申请日：2009-05-22

申请人： Hiroaki Shizuya ,  Larry Green

发明人： Hiroaki Shizuya ,  Larry Green

IPC分类号： A61K39/395 ,  C12N15/63 ,  C12N5/10 ,  C12N5/16 ,  G01N33/566 ,  C12P21/08 ,  C07H21/04 ,  A01K67/027

CPC分类号： A01K67/0275 ,  A01K2217/00 ,  A01K2267/01 ,  C07K16/00 ,  C07K2317/24 ,  C07K2317/52 ,  C07K2317/569 ,  C07K2319/00 ,  C12N15/8509

摘要： The present invention describes methods of generating single VL domain antibodies, including chimeric single chain antibodies that comprise of a variable region of a human immunoglobulin κ or λ light chain and a non-human constant region. The non-human constant region is devoid of a first constant domain CH1, and the variable region is devoid of a heavy chain variable domain.

摘要翻译： 本发明描述了产生单一VL结构域抗体的方法，包括包含人免疫球蛋白的可变区的嵌合单链抗体; 或λ轻链和非人恒定区。 非人恒定区缺少第一恒定结构域CH1，并且可变区缺失重链可变结构域。

公开(公告)号：US20080187531A1

公开(公告)日：2008-08-07

申请号：US11876669

申请日：2007-10-22

申请人： John S. Babcook ,  Jaspal S. Kang ,  Orit Foord ,  Larry Green ,  Xiao Feng ,  Scott Klakamp ,  Mary Haak-Frendscho ,  Palaniswami Rathanaswami ,  Craig Pigott ,  Meina Liang ,  Yen-Wah "Rozanne" Lee ,  Kathy Manchulenko ,  Raffaella Faggioni ,  Giorgio Senaldi ,  Qiaojuan Jane Su

发明人： John S. Babcook ,  Jaspal S. Kang ,  Orit Foord ,  Larry Green ,  Xiao Feng ,  Scott Klakamp ,  Mary Haak-Frendscho ,  Palaniswami Rathanaswami ,  Craig Pigott ,  Meina Liang ,  Yen-Wah "Rozanne" Lee ,  Kathy Manchulenko ,  Raffaella Faggioni ,  Giorgio Senaldi ,  Qiaojuan Jane Su

IPC分类号： A61K39/395 ,  C07K16/00

CPC分类号： C07K16/241 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2317/76 ,  C07K2317/92

摘要： Antibodies directed to the antigen TNFα and uses of such antibodies. In particular, fully human monoclonal antibodies directed to the antigen TNFα. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies.

摘要翻译： 针对抗原TNFα的抗体和这种抗体的用途。 特别是针对抗原TNFα的完全人单克隆抗体。 编码的核苷酸序列和包含重链和轻链免疫球蛋白分子的氨基酸序列，特别是对应于跨越框架区和/或互补决定区（CDR）的连续重链和轻链序列的序列，特别是从FR1至FR4或CDR1至CDR3 。 表达这种免疫球蛋白分子和单克隆抗体的杂交瘤或其它细胞系。

公开(公告)号：US20070166308A1

公开(公告)日：2007-07-19

申请号：US11484247

申请日：2006-07-10

申请人： Nicholas Pullen ,  Elizabeth Molloy ,  Sirid-Aimee Kellermann ,  Larry Green ,  Mary Haak-Frendscho

发明人： Nicholas Pullen ,  Elizabeth Molloy ,  Sirid-Aimee Kellermann ,  Larry Green ,  Mary Haak-Frendscho

IPC分类号： A61K39/395 ,  C12N5/06 ,  C07K16/28

CPC分类号： C07K16/2803 ,  A61K2039/505 ,  C07K14/70503 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/56972 ,  G01N33/6854 ,  G01N2333/70503 ,  G01N2333/70546

摘要： The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that specifically bind to MAdCAM, preferably human MAdCAM and that function to inhibit MAdCAM. The invention also relates to human anti-MAdCAM antibodies and antigen-binding portions thereof. The invention also relates to antibodies that are chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulins derived from human anti-MAdCAM antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti-MAdCAM antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-MAdCAM antibodies. The invention also relates to transgenic animals or plants comprising nucleic acid molecules of the invention.

摘要翻译： 本发明涉及特异性结合MAdCAM，优选人MAdCAM的人抗体及其抗原结合部分的抗体，其功能是抑制MAdCAM。 本发明还涉及人抗MAdCAM抗体及其抗原结合部分。 本发明还涉及嵌合，双特异性，衍生的单链抗体或融合蛋白的部分的抗体。 本发明还涉及衍生自人抗MAdCAM抗体的分离的重链和轻链免疫球蛋白和编码这种免疫球蛋白的核酸分子。 本发明还涉及制备人抗MAdCAM抗体的方法，包含这些抗体的组合物和使用抗体和组合物进行诊断和治疗的方法。 本发明还提供使用编码包含人抗MAdCAM抗体的重和/或轻免疫球蛋白分子的核酸分子的基因治疗方法。 本发明还涉及包含本发明的核酸分子的转基因动物或植物。

公开(公告)号：US09062113B2

公开(公告)日：2015-06-23

申请号：US12268363

申请日：2008-11-10

申请人： Richard Weber ,  Xiao Feng ,  Orit Foord ,  Larry Green ,  Jean Gudas ,  Bruce Keyt ,  Ying Liu ,  Palaniswami Rathanaswami ,  Robert Raya ,  Xiao Dong Yang ,  Jose Corvalan ,  Ian Foltz ,  Xiao-Chi Jia ,  Jaspal S. Kang ,  Chadwick T. King ,  Scott L. Klakamp ,  Qiaojuan Jane Su

发明人： Richard Weber ,  Xiao Feng ,  Orit Foord ,  Larry Green ,  Jean Gudas ,  Bruce Keyt ,  Ying Liu ,  Palaniswami Rathanaswami ,  Robert Raya ,  Xiao Dong Yang ,  Jose Corvalan ,  Ian Foltz ,  Xiao-Chi Jia ,  Jaspal S. Kang ,  Chadwick T. King ,  Scott L. Klakamp ,  Qiaojuan Jane Su

IPC分类号： C12P21/08 ,  C07K16/28 ,  C07K14/705 ,  A61K47/48 ,  B82Y5/00 ,  A61K39/00

CPC分类号： C07K16/30 ,  A61K47/6803 ,  A61K47/6849 ,  A61K47/6897 ,  A61K2039/505 ,  B82Y5/00 ,  C07K16/2863 ,  C07K2317/21 ,  C07K2317/34 ,  C07K2317/77 ,  C07K2317/92 ,  Y10S435/81

摘要： The present invention relates to novel antibodies, particularly antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to the type III deletion mutant, EGFRvIII. The invention also relates to human monoclonal antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to EGFRvIII. Diagnostic and therapeutic formulations of such antibodies, and immunoconjugates thereof, are also provided.

公开(公告)号：US08431130B2

公开(公告)日：2013-04-30

申请号：US12843740

申请日：2010-07-26

申请人： Tariq Ghayur ,  Boris Labkovsky ,  Jeffrey W. Voss ,  Larry Green ,  John Babcook ,  Xiao-chi Jia ,  James Wieler ,  Jaspal Singh Kang ,  Brad Hedberg

发明人： Tariq Ghayur ,  Boris Labkovsky ,  Jeffrey W. Voss ,  Larry Green ,  John Babcook ,  Xiao-chi Jia ,  James Wieler ,  Jaspal Singh Kang ,  Brad Hedberg

IPC分类号： A61K39/395 ,  C07K16/18 ,  C07K16/24 ,  C12P21/08

CPC分类号： C07K16/244 ,  A61K2039/505 ,  C07H21/04 ,  C07K2317/21

摘要： The present invention encompasses IL-18 binding proteins, particularly antibodies that bind human interleukin-18 (hIL-18). Specifically, the invention relates to antibodies that are entirely human antibodies. Preferred antibodies have high affinity for hIL-18 and/or that neutralize hIL-18 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-18 and for inhibiting hIL-18 activity, e.g., in a human subject suffering from a disorder in which hIL-18 activity is detrimental.

摘要翻译： 本发明包括IL-18结合蛋白，特别是结合人白细胞介素-18（hIL-18）的抗体。 具体地，本发明涉及完全是人抗体的抗体。 优选的抗体对hIL-18具有高亲和力和/或在体外和体内中和hIL-18活性。 本发明的抗体可以是全长抗体或其抗原结合部分。 还提供了制备方法和使用本发明抗体的方法。 本发明的抗体或抗体部分可用于检测hIL-18和抑制hIL-18活性，例如在患有hIL-18活性有害的病症的人类受试者中。