- 专利标题: Substituted 2-carbonylamino-6-piperidinaminopyridines and substituted 1-carbonylamino-3-piperidinaminobenzenes as 5-ht 1f agonists
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申请号: US10569109申请日: 2004-09-03
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公开(公告)号: US20060287363A1公开(公告)日: 2006-12-21
- 发明人: Maria-Jesus Blanco-Pillado , Michael Cohen , Sandra Filla , Kevin Hudzlak , Daniel Kohlman , Dana Benesh , Frantz Victor , Yao-Chang Xu , Bai-Ping Ying , DeAnna Zacherl , Deyi Zhang , Brian Mathes
- 申请人: Maria-Jesus Blanco-Pillado , Michael Cohen , Sandra Filla , Kevin Hudzlak , Daniel Kohlman , Dana Benesh , Frantz Victor , Yao-Chang Xu , Bai-Ping Ying , DeAnna Zacherl , Deyi Zhang , Brian Mathes
- 申请人地址: US IN INDIANAPOLIS
- 专利权人: ELLI LILLY AND COMPANY
- 当前专利权人: ELLI LILLY AND COMPANY
- 当前专利权人地址: US IN INDIANAPOLIS
- 国际申请: PCT/US04/25607 WO 20040903
- 主分类号: A61K31/4545
- IPC分类号: A61K31/4545 ; A61K31/454 ; C07D403/14
摘要:
The present invention relates to compounds of formula I: (I) or a pharmaceutically acceptable acid addition salt thereof, where; X is C(R3c═ or N═; R1 is C2-C6 alkyl, substituted C2-C6 alkyl, C3-C7 cycloalkyl, substituted C3-C7 cycloalkyl, phenyl, substituted phenyl, heterocycle, or substituted heterocycle; R2 is hydrogen, C1-C3 n-alkyl, C3-C6 cycloalkyl-C1-C3 alkyl, or a group of formula II (II) provided that when R1 is C2-C6 alkyl or substituted C2-C6 alkyl, R2 is hydrogen or methyl; R3a, R3b, and, when X is C(R3c)═, R3c, are each independently hydrogen, fluoro, or methyl, provided that no more than one of R3a, R3b, and R3c may be other than hydrogen; R4 is hydrogen or C1-C3 alkyl; R5 is hydrogen, C1-C3 alkyl, or C3-C6 cycloalkylcarbonyl, provided that when R3a is other than hydrogen, R5 is hydrogen; R6 is hydrogen or C1-C6 alkyl; and n is an integer from 1 to 6 inclusively. The compounds of the present invention are useful for activating 5-HT1F receptors, inhibiting neuronal protein extravasation, and for the treatment or prevention of migraine in a mammal.
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