发明申请
US20060293326A1 2-Heteroaryl-imidazotriazinones and their use in the treatment of inflammatory or immune diseases
审中-公开
2-杂芳基 - 咪唑并三嗪酮及其在治疗炎症或免疫疾病中的应用
- 专利标题: 2-Heteroaryl-imidazotriazinones and their use in the treatment of inflammatory or immune diseases
- 专利标题(中): 2-杂芳基 - 咪唑并三嗪酮及其在治疗炎症或免疫疾病中的应用
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申请号: US10480949申请日: 2002-05-21
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公开(公告)号: US20060293326A1公开(公告)日: 2006-12-28
- 发明人: Cristina Alonso-Alija , Heike Gielen , Martin Hendrix , Ulrich Niewohner , Maria Niewohner , Dagmar Schauss , Hilmar Bischoff , Nils Burkhardt , Volker Geiss , Karl-Heinz Schlemmer , Nigel Cuthbert , Mary Fitzgerald , Graham Sturton
- 申请人: Cristina Alonso-Alija , Heike Gielen , Martin Hendrix , Ulrich Niewohner , Maria Niewohner , Dagmar Schauss , Hilmar Bischoff , Nils Burkhardt , Volker Geiss , Karl-Heinz Schlemmer , Nigel Cuthbert , Mary Fitzgerald , Graham Sturton
- 优先权: GB0113343.8 20010601
- 国际申请: PCT/EP02/05540 WO 20020521
- 主分类号: A61K31/53
- IPC分类号: A61K31/53 ; C07D487/04
摘要:
The invention relates to 2-Heteroaryl-imidazotriazinones, processes for their preparation and their use in medicaments, esp. for the treatment and/or prophylaxis of inflammatory processes and/or immune diseases. The present invention relates to compounds of the general formula (I) in which R1 denotes 5- to 10-membered heteroaryl, which is optionally substituted by identical or different residues selected from the group consisting of halogen, (C1-C4)-alkyl, trifluoromthyl, cyano, nitro und trifluoromethoxy, denotes 3- to 10-membered carbocyclyl or carbon-bonded, 4- to 10-membered heterocyclyl, whereby carbocyclyl and heterocyclyl are optionally substituted by identical or different residues selected from the group consisting of (C1-C6)-aldyl, (C1-C6)-aldoxy, hydroxy, halogen, trifluoromethyl and oxo, or denotes (C2-C10)-alkyl, which is optionally substituted by identical or different residues selected from the group the group consisting of (C1-C6)-alkoxy, hydroxy, halogen, 3- to 10-membered carbocyclyl and oxo.
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