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公开(公告)号：US20120142728A1
公开(公告)日：2012-06-07
申请号：US13398290
申请日：2012-02-16
申请人： Hilmar BISCHOFF , Heike GIELEN-HAERTWIG , Volkhart LI , Carsten SCHMECK , Michael THUTEWOHL , Alexandros VAKALOPOULOS , Olaf WEBER , Martina WUTTKE
发明人： Hilmar BISCHOFF , Heike GIELEN-HAERTWIG , Volkhart LI , Carsten SCHMECK , Michael THUTEWOHL , Alexandros VAKALOPOULOS , Olaf WEBER , Martina WUTTKE
CPC分类号： C07D215/20
摘要： The present application relates to a novel tetrahydroquinoline derivative, to a process for its preparation, to its use on its own or in combination for treating and/or preventing diseases and to its use for preparing medicaments, in particular as an inhibitor of the cholesterol ester transfer protein (CETP) for the treatment and/or prevention of cardiovascular disorders, in particular hypolipoproteinaemias, dyslipidaemias, hypertriglyceridaemias, hyperlipidaemias, hypercholesterolaemias and arteriosclerosis.
摘要翻译： 本申请涉及一种新的四氢喹啉衍生物，其制备方法，其单独使用或组合用于治疗和/或预防疾病及其用于制备药物的用途，特别是作为胆固醇酯的抑制剂 转运蛋白（CETP）用于治疗和/或预防心血管疾病，特别是下皮脂蛋白血症，血脂异常，高甘油三酯血症，高脂血症，高胆固醇血症和动脉硬化。
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公开(公告)号：US08039629B2
公开(公告)日：2011-10-18
申请号：US11793482
申请日：2005-12-15
申请人： Hilmar Bischoff , Heike Gielen-Haertwig , Volkhart Li , Carsten Schmeck , Michael Thutewohl , Alexandros Vakalopoulos , Olaf Weber , Martina Wuttke
发明人： Hilmar Bischoff , Heike Gielen-Haertwig , Volkhart Li , Carsten Schmeck , Michael Thutewohl , Alexandros Vakalopoulos , Olaf Weber , Martina Wuttke
IPC分类号： C07D215/38
摘要： The present application relates to a novel tetrahydroquinoline derivative, to a process for its preparation, to its use on its own or in combination for treating and/or preventing diseases and to its use for preparing medicaments, in particular as an inhibitor of the cholesterol ester transfer protein (CETP) for the treatment and/or prevention of cardiovascular disorders, in particular hypolipoproteinaemias, dyslipidaemias, hypertriglyceridaemias, hyperlipidaemias, hypercholesterolaemias and arteriosclerosis.
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公开(公告)号：US20100184788A1
公开(公告)日：2010-07-22
申请号：US12633723
申请日：2009-12-08
申请人： Heike GIELEN-HAERTWIG , Barbara Albrecht , Jörg Keldenich , Volkhart Li , Josef Pernerstorfer , Karl-Heinz Schlemmer , Leila Telan
发明人： Heike GIELEN-HAERTWIG , Barbara Albrecht , Jörg Keldenich , Volkhart Li , Josef Pernerstorfer , Karl-Heinz Schlemmer , Leila Telan
IPC分类号： A61K31/513 , C07D239/34 , A61P9/00
CPC分类号： C07D239/22 , C07D401/04 , C07D401/06 , C07D405/06 , C07D405/14 , C07D409/10 , C07D413/06 , C07D413/14
摘要： The invention relates to novel heterocyclic derivatives of the general formula (I), processes for their preparation, and their use in medicaments, especially for the treatment of chronic obstructive pulmonary diseases, acute coronary syndrome, acute myocardial infarction, and heart failure development.
摘要翻译： 本发明涉及通式（I）的新型杂环衍生物，其制备方法及其在药物中的用途，特别是用于治疗慢性阻塞性肺疾病，急性冠状动脉综合征，急性心肌梗死和心力衰竭发展。
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公开(公告)号：US20100003709A1
公开(公告)日：2010-01-07
申请号：US11793367
申请日：2005-12-13
申请人： Peter Reinemer , Heike Gielen-Haertwig , Ulrich Rosentreter , Volkhart Li , Axel Harrenga , Dietmar Schomburg , Karsten Niefind , Guido Hansen
发明人： Peter Reinemer , Heike Gielen-Haertwig , Ulrich Rosentreter , Volkhart Li , Axel Harrenga , Dietmar Schomburg , Karsten Niefind , Guido Hansen
IPC分类号： C12Q1/37 , C12N9/66 , G06G7/48 , C07D239/22
CPC分类号： C07D239/36 , C07K2299/00 , C12N9/6448 , C12Y304/21037
摘要： This invention relates to crystallised human neutrophil elastase and the use of its three-dimensional structure to design modulators for human neutrophil elastase.
摘要翻译： 本发明涉及结晶人嗜中性粒细胞弹性蛋白酶及其三维结构用于设计人嗜中性粒细胞弹性蛋白酶调节剂的用途。
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公开(公告)号：US07230017B2
公开(公告)日：2007-06-12
申请号：US10525608
申请日：2003-08-18
申请人： Heike Gielen-Haertwig , Volkhart Min-Jian Li , Ulrich Rosentreter , Karl-Heinz Schlemmer , Swen Allerheiligen , Leila Telan , Lars Bärfacker , Jörg Keldenich , Mary F. Fitzgerald , Kevin Nash , Barbara Albrecht , Dirk Meurer
发明人： Heike Gielen-Haertwig , Volkhart Min-Jian Li , Ulrich Rosentreter , Karl-Heinz Schlemmer , Swen Allerheiligen , Leila Telan , Lars Bärfacker , Jörg Keldenich , Mary F. Fitzgerald , Kevin Nash , Barbara Albrecht , Dirk Meurer
IPC分类号： A61K31/4412 , A61K31/444 , A61K31/5377 , A61K31/4439 , A61K31/4436 , A61K31/496 , A61K31/4545 , C07D401/02 , C07D413/02 , C07D211/86 , C07D213/22 , C07D417/02
CPC分类号： C07D401/04 , C07D211/90 , C07D405/04 , C07F7/1804
摘要： The invention relates to novel dihydropyridinone derivatives, processes for their preparation, and their use in medicaments, especially for the treatment of chronic obstructive pulmonary diseases, acute coronary syndrome, acute myocardial infarction and heart failure development.
摘要翻译： 本发明涉及新的二氢吡啶酮衍生物，其制备方法及其在药物中的用途，特别是用于治疗慢性阻塞性肺疾病，急性冠状动脉综合征，急性心肌梗塞和心力衰竭发展。
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公开(公告)号：US20060111377A1
公开(公告)日：2006-05-25
申请号：US10527386
申请日：2003-08-28
申请人： Heike Gielen-Haertwig , Volkhart Li , Ulrich Rosentreter , Karl-Heinz Schlemer , Swen Sllerheiligen , Leila Telan , Lars Barfacker , Jorg Keldenich , Mary Fitzgerald , Kevin Nash , Barbara Albrecht , Dirk Meurer
发明人： Heike Gielen-Haertwig , Volkhart Li , Ulrich Rosentreter , Karl-Heinz Schlemer , Swen Sllerheiligen , Leila Telan , Lars Barfacker , Jorg Keldenich , Mary Fitzgerald , Kevin Nash , Barbara Albrecht , Dirk Meurer
IPC分类号： A61K31/513 , C07D403/04 , C07D239/32
CPC分类号： C07D239/22 , C07D401/12 , C07D403/12 , C07D413/12 , C07D417/12
摘要： The invention relates to novel heterocyclic derivatives, processes for their preparation, and their use in medicaments, especially for the treatment of chronic obstructive pulmonary diseases, acute coronary syndrome, acute myocardial infarction and heart failure development.
摘要翻译： 本发明涉及新型杂环衍生物，其制备方法及其在药物中的用途，特别是用于治疗慢性阻塞性肺疾病，急性冠状动脉综合征，急性心肌梗死和心力衰竭发展。
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公开(公告)号：US20050065153A1
公开(公告)日：2005-03-24
申请号：US10964380
申请日：2004-10-12
申请人： Cristina Alonso-Alija , Heike Gielen , Martin Hendrix , Ulrich Niewohner , Dagmar Schauss , Hilmar Bischoff , Nils Burkhardt , Volker Geiss , Karl-Heinz Schlemmer , Nigel Cuthbert , Mary Fitzgerald , Graham Sturton , Maria Niewohner
发明人： Cristina Alonso-Alija , Heike Gielen , Martin Hendrix , Ulrich Niewohner , Dagmar Schauss , Hilmar Bischoff , Nils Burkhardt , Volker Geiss , Karl-Heinz Schlemmer , Nigel Cuthbert , Mary Fitzgerald , Graham Sturton , Maria Niewohner
IPC分类号： C07D253/06 , A61K31/53 , A61P11/00 , A61P11/06 , A61P29/00 , A61P37/02 , C07D253/07 , C07D487/04
CPC分类号： C07D253/07 , C07D487/04
摘要： The invention relates to 7-(4-tert butyl-cyclohexyl)-imidazotriazinones, processes for their preparation and their use in medicaments, esp. for the treatment and/or prophylaxis of inflammatory processes and/or immune diseases.
摘要翻译： 本发明涉及7-（4-叔丁基 - 环己基） - 咪唑并三嗪酮，其制备方法及其在药物中的应用， 用于治疗和/或预防炎症过程和/或免疫疾病。
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8.发明授权Pyrimidinone derivatives as therapeutic agents against acute and chronic inflammatory, ischaemic and remodelling processes 有权嘧啶酮衍生物作为抗急性和慢性炎性，缺血和重塑过程的治疗剂公开(公告)号：US07687510B2
公开(公告)日：2010-03-30
申请号：US10527391
申请日：2003-08-28
申请人： Heike Gielen-Haertwig , Volkhart Min-Jian Li , Ulrich Rosentreter , Karl-Heinz Schlemmer , Swen Allerheiligen , Leila Telan , Lars Bärfacker , Jörg Keldenich , Mary F. Fitzgerald , Kevin Nash , Barbara Albrecht , Dirk Meurer
发明人： Heike Gielen-Haertwig , Volkhart Min-Jian Li , Ulrich Rosentreter , Karl-Heinz Schlemmer , Swen Allerheiligen , Leila Telan , Lars Bärfacker , Jörg Keldenich , Mary F. Fitzgerald , Kevin Nash , Barbara Albrecht , Dirk Meurer
IPC分类号： C07D239/22 , C07D401/04 , A61K31/5377
CPC分类号： C07D239/22 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/06 , C07D405/12 , C07D413/04 , C07D413/12 , C07D417/04 , C07D417/12
摘要： The invention relates to novel heterocyclic derivatives, processes for their preparation, and their use in medicaments, especially for the treatment of chronic obstructive pulmonary diseases.
摘要翻译： 本发明涉及新型杂环衍生物，其制备方法及其在药物中的用途，特别是用于治疗慢性阻塞性肺疾病。
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9.发明申请I-PHENY 1-3,4-DIHYDROPYRIMIDIN-2(1H)-ONE DERIVATIVES AND THEIR USE 失效I-PHENY 1-3,4-二羟基嘧啶-2（1H） - 酮衍生物及其用途公开(公告)号：US20100022537A1
公开(公告)日：2010-01-28
申请号：US12509936
申请日：2009-07-27
申请人： Heike Gielen-Haertwig , Volkhart Min-Jian Li , Ulrich Rosentreter , Karl-Heinz Schlemmer , Swen Allerheiligen , Leila Telan , Lars Bärfacker , Jörg Keldenieh , Mary F. Fitzgerald , Kevin Nash , Barbara Albrecht , Dirk Meurer
发明人： Heike Gielen-Haertwig , Volkhart Min-Jian Li , Ulrich Rosentreter , Karl-Heinz Schlemmer , Swen Allerheiligen , Leila Telan , Lars Bärfacker , Jörg Keldenieh , Mary F. Fitzgerald , Kevin Nash , Barbara Albrecht , Dirk Meurer
IPC分类号： A61K31/5377 , C07D239/02 , A61K31/505 , C07D413/02 , A61P29/00 , A61P9/00
CPC分类号： C07D239/22 , C07D401/12 , C07D403/12 , C07D413/12 , C07D417/12
摘要： This invention relates to novel heterocyclic derivatives, processes for their preparation, and their use in medicaments, especially for the treatment of chronic obstructive pulmonary diseases, acute coronary syndrome, acute myocardial infarction and heart failure development.
摘要翻译： 本发明涉及新型杂环衍生物，其制备方法及其在药物中的用途，特别是用于治疗慢性阻塞性肺疾病，急性冠状动脉综合征，急性心肌梗塞和心力衰竭发展。
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公开(公告)号：US07115602B2
公开(公告)日：2006-10-03
申请号：US10160352
申请日：2002-05-30
申请人： Cristina Alonso-Alija , Heike Gielen , Martin Hendrix , Maria Niewöhner , Dagmar Schauss , Hilmar Bischoff , Nils Burkhardt , Volker Geiss , Karl-Heinz Schlemmer , Nigel J. Cuthbert , Mary F. Fitzgerald , Graham Sturton
发明人： Ulrich Niewöhner
IPC分类号： A01N43/64 , A61K31/53 , C07D487/00
CPC分类号： C07D253/07 , C07D487/04
摘要： The invention relates to 7-(4-tert butyl-cyclohexyl)-imidazotriazinones, processes for their preparation and their use in medicaments, esp. for the treatment and/or prophylaxis of inflammatory processes and/or immune diseases.
摘要翻译： 本发明涉及7-（4-叔丁基 - 环己基） - 咪唑并三嗪酮，其制备方法及其在药物中的应用， 用于治疗和/或预防炎症过程和/或免疫疾病。
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