发明申请
US20070004630A1 Functional role of adrenomedullin (AM) and the gene-related product (PAMP) in human pathology and physiology
失效
肾上腺髓质素（AM）和基因相关产物（PAMP）在人类病理和生理学中的功能作用
- 专利标题： Functional role of adrenomedullin (AM) and the gene-related product (PAMP) in human pathology and physiology
- 专利标题（中）： 肾上腺髓质素（AM）和基因相关产物（PAMP）在人类病理和生理学中的功能作用
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申请号： US11517599申请日： 2006-09-05
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公开(公告)号： US20070004630A1公开(公告)日： 2007-01-04
- 发明人: Frank Cuttitta , Alfredo Martinez , Mae Miller , Edward Unsworth , William Hook , Thomas Walsh , Karen Gray , Charles Macri
- 申请人： Frank Cuttitta , Alfredo Martinez , Mae Miller , Edward Unsworth , William Hook , Thomas Walsh , Karen Gray , Charles Macri
- 专利权人： The Gov. of the USA as represented by the Sec. of the Department of Health and Human Services
- 当前专利权人： The Gov. of the USA as represented by the Sec. of the Department of Health and Human Services
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; A61K38/22
摘要：
The methods of the present invention demonstrate that adrenomedullin (AM) is expressed in human cancer cell lines of diverse origin and functions as a universal autocrine growth factor driving neoplastic proliferation. The present invention provides for AM peptides and AM antibodies useful in therapeutic, pharmacologic and physiologic compositions. The present invention additionally provides for methods of diagnosis, treatment and prevention of disease utilizing compositions comprising the AM peptides and antibodies of the present invention. The methods of the present invention also provide for experimental models for use in identifying the role of AM in pancreatic physiology. The methods pertaining to rat isolated islets have show that AM inhibits insulin secretion in a dose-dependent manner. The monoclonal antibody MoAb-G6, which neutralizes AM bioactivity, was show by the methods of the present invention to increase insulin release fivefold, an effect that was reversed by the addition of synthetic AM.
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