公开(公告)号：US20070004630A1

公开(公告)日：2007-01-04

申请号：US11517599

申请日：2006-09-05

申请人： Frank Cuttitta ,  Alfredo Martinez ,  Mae Miller ,  Edward Unsworth ,  William Hook ,  Thomas Walsh ,  Karen Gray ,  Charles Macri

发明人： Frank Cuttitta ,  Alfredo Martinez ,  Mae Miller ,  Edward Unsworth ,  William Hook ,  Thomas Walsh ,  Karen Gray ,  Charles Macri

IPC分类号： A61K39/395 ,  A61K38/22

CPC分类号： C07K16/26 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/505 ,  A61K2039/51 ,  C07K14/575 ,  C07K2317/34 ,  C07K2317/73

摘要： The methods of the present invention demonstrate that adrenomedullin (AM) is expressed in human cancer cell lines of diverse origin and functions as a universal autocrine growth factor driving neoplastic proliferation. The present invention provides for AM peptides and AM antibodies useful in therapeutic, pharmacologic and physiologic compositions. The present invention additionally provides for methods of diagnosis, treatment and prevention of disease utilizing compositions comprising the AM peptides and antibodies of the present invention. The methods of the present invention also provide for experimental models for use in identifying the role of AM in pancreatic physiology. The methods pertaining to rat isolated islets have show that AM inhibits insulin secretion in a dose-dependent manner. The monoclonal antibody MoAb-G6, which neutralizes AM bioactivity, was show by the methods of the present invention to increase insulin release fivefold, an effect that was reversed by the addition of synthetic AM.

摘要翻译： 本发明的方法证明，肾上腺髓质素（AM）在不同来源的人类癌细胞系中表达，并且作为驱动肿瘤增殖的通用自分泌生长因子起作用。 本发明提供可用于治疗，药理和生理组合物的AM肽和AM抗体。 本发明另外提供了使用包含本发明的AM肽和抗体的组合物来诊断，治疗和预防疾病的方法。 本发明的方法还提供了用于鉴定AM在胰腺生理学中的作用的实验模型。 与大鼠分离的胰岛有关的方法表明，AM以剂量依赖的方式抑制胰岛素分泌。 中和AM生物活性的单克隆抗体MoAb-G6通过本发明的方法显示出增加胰岛素释放的五倍，这是通过加入合成AM而逆转的作用。

公开(公告)号：US07101548B2

公开(公告)日：2006-09-05

申请号：US09931700

申请日：2001-08-16

申请人： Frank Cuttitta ,  Alfredo Martinez ,  Mae Jean Miller ,  Edward J. Unsworth ,  William Hook ,  Thomas Walsh ,  Karen Gray ,  Charles Macri

发明人： Frank Cuttitta ,  Alfredo Martinez ,  Mae Jean Miller ,  Edward J. Unsworth ,  William Hook ,  Thomas Walsh ,  Karen Gray ,  Charles Macri

IPC分类号： A61K39/395

CPC分类号： C07K16/26 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/505 ,  A61K2039/51 ,  C07K14/575 ,  C07K2317/34 ,  C07K2317/73

摘要： The methods of the present invention demonstrate that adrenomedullin (AM) is expressed in human cancer cell lines of diverse origin and functions as a universal autocrine growth factor driving neoplastic proliferation. The present invention provides for AM peptides and AM antibodies useful in therapeutic, pharmacologic and physiologic compositions. The present invention additionally provides for methods of diagnosis, treatment and prevention of disease utilizing compositions comprising the AM peptides and antibodies of the present invention. The methods of the present invention also provide for experimental models for use in identifying the role of AM in pancreatic physiology. The methods pertaining to rat isolated islets have shown that AM inhibits insulin secretion in a dose-dependent manner. The monoclonal antibody MoAb-G6, which neutralizes AM bioactivity, was shown by the methods of the present invention to increase insulin release fivefold, an effect that was reversed by the addition of synthetic AM.

摘要翻译： 本发明的方法证明，肾上腺髓质素（AM）在不同来源的人类癌细胞系中表达，并且作为驱动肿瘤增殖的通用自分泌生长因子起作用。 本发明提供可用于治疗，药理和生理组合物的AM肽和AM抗体。 本发明另外提供了使用包含本发明的AM肽和抗体的组合物来诊断，治疗和预防疾病的方法。 本发明的方法还提供了用于鉴定AM在胰腺生理学中的作用的实验模型。 与大鼠分离的胰岛相关的方法已经表明AM以剂量依赖的方式抑制胰岛素分泌。 通过本发明的方法显示了中和AM生物活性的单克隆抗体MoAb-G6，以增加胰岛素释放的五倍，这是通过加入合成AM而逆转的作用。

公开(公告)号：US06320022B1

公开(公告)日：2001-11-20

申请号：US09011922

申请日：1998-02-17

申请人： Frank Cutitta ,  Alfredo Martinez ,  Mae Jean Miller ,  Edward J. Unsworth ,  William Hook ,  Thomas Walsh ,  Karen Gray ,  Charles Macri

发明人： Frank Cutitta ,  Alfredo Martinez ,  Mae Jean Miller ,  Edward J. Unsworth ,  William Hook ,  Thomas Walsh ,  Karen Gray ,  Charles Macri

IPC分类号： A61K3800

CPC分类号： C07K16/26 ,  A61K38/00 ,  A61K39/00 ,  A61K2039/505 ,  A61K2039/51 ,  C07K14/575 ,  C07K2317/34 ,  C07K2317/73

摘要： The methods of the present invention demonstrate that adrenomedullin (AM) is expressed in human cancer cell lines of diverse origin and functions as a universal autocrine growth factor driving neoplastic proliferation. The present invention provides for AM peptides and AM antibodies useful in therapeutic, pharmacologic and physiologic compositions. The present invention additionally provides for methods of diagnosis, treatment and prevention of disease utilizing compositions comprising the AM peptides and antibodies of the present invention. The methods of the present invention also provide for experimental models for use in identifying the role of AM in pancreatic physiology. The methods pertaining to rat isolated islets have shown that AM inhibits insulin secretion in a dose-dependent manner. The monoclonal antibody MoAb-G6, which neutralizes AM bioactivity, was shown by the methods of the present invention to increase insulin release fivefold, an effect that was reversed by the addition of synthetic AM.

摘要翻译： 本发明的方法证明，肾上腺髓质素（AM）在不同来源的人类癌细胞系中表达，并且作为驱动肿瘤增殖的通用自分泌生长因子起作用。 本发明提供可用于治疗，药理和生理组合物的AM肽和AM抗体。 本发明另外提供了使用包含本发明的AM肽和抗体的组合物来诊断，治疗和预防疾病的方法。 本发明的方法还提供了用于鉴定AM在胰腺生理学中的作用的实验模型。 与大鼠分离的胰岛相关的方法已经表明AM以剂量依赖的方式抑制胰岛素分泌。 通过本发明的方法显示了中和AM生物活性的单克隆抗体MoAb-G6，以增加胰岛素释放的五倍，这是通过加入合成AM而逆转的作用。

公开(公告)号：US20080027644A1

公开(公告)日：2008-01-31

申请号：US11855129

申请日：2007-09-13

申请人： Larry Spencer ,  Mike Mouser ,  Jeffrey Millington ,  Roger Stevens ,  Christopher Hook ,  William Hook

发明人： Larry Spencer ,  Mike Mouser ,  Jeffrey Millington ,  Roger Stevens ,  Christopher Hook ,  William Hook

IPC分类号： G01C21/00

CPC分类号： G01C21/265 ,  G01C21/26

摘要： A navigation system includes an operator interface module (OIM) including a display and keypad. A computer module (computer module) includes a CPU, map database and the motion and position sensors. A docking station is fixedly mounted in each of a plurality of vehicles. The docking station includes an electrical connector connected to the vehicle power supply and an electrical connector connected to a GPS antenna and an electrical connector connected to a display extension harness. The computer module and OIM are transportable among each of the vehicles. The computer module slides into the docking station and simultaneously makes electrical contact with the vehicle power supply, GPS antenna and display extension harness. The OIM is connected to the display extension harness, thereby connecting the OIM to the computer module. The OIM and computer module are thus transportable among multiple vehicles having the appropriate docking station.

摘要翻译： 导航系统包括包括显示器和小键盘的操作员接口模块（OIM）。 计算机模块（计算机模块）包括CPU，地图数据库以及运动和位置传感器。 对接站固定地安装在多个车辆的每一个中。 对接站包括连接到车辆电源的电连接器和连接到GPS天线的电连接器和连接到显示器延长线束的电连接器。 计算机模块和OIM可在每个车辆之间运输。 计算机模块滑入对接站，同时与车辆电源，GPS天线和显示器延长线束电接触。 OIM连接到显示器扩展线束，从而将OIM连接到计算机模块。 因此，OIM和计算机模块可以在具有适当对接站的多个车辆之间运输。