发明申请
US20070004660A1 Synergistic Modulation of Flt3 Kinase Using Alkylquinolines and Alkylquinazolines
审中-公开
使用烷基喹啉和烷基喹唑啉协同调节Flt3激酶
- 专利标题： Synergistic Modulation of Flt3 Kinase Using Alkylquinolines and Alkylquinazolines
- 专利标题（中）： 使用烷基喹啉和烷基喹唑啉协同调节Flt3激酶
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申请号： US11422395申请日： 2006-06-06
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公开(公告)号： US20070004660A1公开(公告)日： 2007-01-04
- 发明人: Christian Baumann , Michael Gaul , Dana Johnson , Robert Tuman
- 申请人： Christian Baumann , Michael Gaul , Dana Johnson , Robert Tuman
- 主分类号： A61K48/00
- IPC分类号： A61K48/00 ; A61K31/541 ; A61K31/5377 ; A61K31/517 ; A61K31/496
摘要：
The invention is directed to a method of inhibiting FLT3 tyrosine kinase activity or expression or reducing FLT3 kinase activity or expression in a cell or a subject comprising the administration of a farnesyl transferase inhibitor and a FLT3 kinase inhibitor selected from alkylquinoline and alkylquinazoline compounds of Formula I′: where R1, R2, R3, Z, G, Q and X are as defined herein. Included within the present invention is both prophylactic and therapeutic methods for treating a subject at risk of (or susceptible to) developing a cell proliferative disorder or a disorder related to FLT3.
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